Neutrophil Adhesion Markers
| Abbrev Code: | XMISC | ||
| Order Code: | LAB4909 | Order Name: | Neutrophil Adhesion Markers |
| Synonyms: | LAD | ||
| Methodology: | Flow cytometry | ||
| CPT Codes: | 88184 x1, 88185 x1 | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Thur before 1500; results are reported within 7 days. | ||
| Special Instructions: | A signed informed consent in the patient's medical record is required. The completed requisition form should not be sent to the laboratory. A completed requisition form must be sent with each sample. See Associated Links.
Samples must be received at testing site within 24 hours of collection. Order On Time Delivery courier to deliver directly to East Bank Sendouts Lab. Call Sendouts at 612-273-3711 to notify. CSC and West only: Send in red STAT bag by Associated courier. Call Sendouts at 612-273-3711 to notify. |
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| Associated Links: | Genetic Testing Consent Form, Cincinnati Children's Hospital Requisition Form |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 1 mL |
| Minimum\Peds Volume: | 1 mL |
| Container: | Purple (EDTA) |
| Collection Instructions: | Specimens must be collected after 10:00 am and received in East Bank Core Lab by 1400 Monday through Thursday. Do not collect the day before a holiday. |
| Causes for Rejection: | Specimens greater than 24 hours old. Refrigerated or frozen specimens. Clotted, hemolyzed or centrifuged specimens. |
Processing and Shipping
| Specimen Processing: | Whole blood. Do not process. |
| Shipping Instructions: | Ship sample same day at room temperature. Must arrive at testing site within 24 hours of collection and before 17:00 on Fridays. Call CBDI DIL at 513-636-4685 with courier and sample tracking number. |
| Test Performed at or Referral Lab | Lab Sendouts (Cincinnati Children's Hospital Medical Center) |
| Referral Lab number: | 2902070 |
Interpretive
| Reference Range: | By report |
| Use: |
CD11b/CD18 and its endothelial cell ligands including intracellular adhesion molecule-1 (ICAM-1, CD54) are necessary for firm neutrophil adherence and transendothelial migration. Leukocyte adhesion deficiency syndrome type 1 (LAD-1) results from a congenital deficiency of the leukocyte b2 intergrin receptor complex CD11/CD18 on the cell surface.
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