Porphyrins and Porphobilinogen, Urine


Abbrev Code:PORPOR   
Order Code:LAB6041Order Name:Porphyrins and Porphobilinogen, Urine
Methodology:High performance liquid chromatography/ Ion exchange chromatography/Spectrophotometry
CPT Codes: 84120 x1, 84110 x1
Turnaround Time:Specimens are sent to the reference laboratory Mon-Sat; results are reported within 2-5 days.
Special Instructions:Total volume and collection time interval is required.
Compliance:

For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
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Urine Collection Procedure


Collection Instructions

Specimen:Urine, timed or random collection
Optimal Volume:Submit entire collection; analysis requires 8 mL (4 mL minimum).
Container:3 L plastic jug
Alternate Containers: Plastic leakproof container, sterile
Collection Instructions:Refrigerate during 24 hour collection.
Causes for Rejection:Not protected from light; stored at room temperature. Body fluids other than urine.


Processing and Shipping

Specimen Processing:Aliquot 8 mL, 4 mL minimum. Protect from light. Store in freezer. Accepted up to 4 days after collection if refrigerated and light protected. Record total volume and collection time interval on transport tube.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2002181


Interpretive

Reference Range:

Uroporphyrin

0-4 µmol/mol crt

Heptacarboxylate Porphyrin

0-2 µmol/mol crt

Coproporphyrin I

0-6 µmol/mol crt

Coproporphyrin III

0-14 µmol/mol crt

Porphobilinogen, Urine

0.0-8.8 µmol/

Porphobilinogen, Urine (24-hour)

0.0-11.0 µmol/d*

*Results are normalized to creatinine concentration and reported as a ratio of amounts (micromoles of porphyrin/moles of creatinine.)

 

Use:Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Urine porphobilinogen (PBG) is useful for the evaluation of neurologic and/or psychiatric symptoms to exclude acute porphyrias such as acute intermittent porphyria (AIP).


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