Free Kappa and Lambda Light Chains, Quantitative, Urine

Abbrev Code:ARMISC   
Order Code:LAB4909Order Name:Send Outs Misc Test
Synonyms:Immunofixation with Free Light Chains, Quantitative; Kappa, Lambda Light Chains, Bence Jones Proteins
Methodology:Immunofixation electrophoresis; Immunoturbidimetry
CPT Codes: 83520 x2, 84156 x1, 86335 x1
Turnaround Time:Specimens are sent to the reference laboratory Mon-Sat; results are reported within 2-6 days.
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Urine Collection Procedure

Collection Instructions

Specimen:Urine, 24 hour collection or random
Optimal Volume:Submit entire 24 collection; analysis requires 4 mL minimum
Container:Plastic leakproof container, sterile
Collection Instructions:Refrigerate during collection.
Causes for Rejection:Room temperature specimens.

Processing and Shipping

Specimen Processing:Mix collection well before aliquot is taken. Transfer specimen to two 4 mL aliquots; one 4 mL aliquot minimum. Store in refrigerator. Record total volume and collection time interval on transport tube and test request form.
Shipping Instructions:Ship at refrigerated temperature.
Stability:3 weeks refrigerated; 6 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3002104


Reference Range:
Total Protein Less than 150 mg/d
Free Urinary Kappa Light Chains 0.00-32.90 mg/L
Free Urinary Kappa Excretion/Day By report
Free Urinary Lambda Light Chain 0.00-3.79 mg/L
Free Urinary Lambda Excretion/Day By report
IFE Interpretation By report
Use:Results of urine free light chain testing can be used to monitor disease progression or response to therapy in patients for whom urine electrophoresis is unable to provide reliable Bence Jones Protein quantification. The results of urine kappa and lambda free light chain quantitative values may be misleading in specimens with high levels of urinary polyclonal free light chains, and absent Bence Jones protein by immunofixation; therefore correlation with urine immunofixation is required to identify inconsistent results.

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