Aquaporin-4 Receptor Antibody, IgG by IFA with Reflex to Titer
| Abbrev Code: | NMOA4G | ||
| Order Code: | LAB6883 | Order Name: | Neuromyelitis Optica AQP4 IGG with reflex blood |
| Synonyms: | AQP; AQP4; NMO; Neuromyelitis Optica | ||
| Methodology: | Semi-quantitative indirect fluorescent antibody | ||
| CPT Codes: | 86052 x1, 86052 x1 | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-6 days. | ||
| Compliance: | For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes. |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2 mL |
| Minimum\Peds Volume: | 0.5 mL |
| Container: | Red or gold (gel) Alternate Containers: Red (no gel) |
| Causes for Rejection: | Contaminated specimens. |
Processing and Shipping
| Specimen Processing: | Separate serum from cells ASAP. Centrifuge and aliquot 1 mL, 0.15 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | 48 hours at room temperature; 2 weeks refrigerated; 1 year frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 2013320 |
Interpretive
| Reference Range: | Aquaporin-4 Receptor Antibody IgG by IFA with Reflex to Titer, Serum: Less than 1:10 |
| Use: | Diagnosis of neuromyelitis optica (NMO) requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis. Approximately 75 percent of patients with NMO express antibodies to the aquaporin-4 (AQP4) receptor. While the absence of AQP4 receptor antibodies does not rule out a diagnosis of NMO, presence of this antibody is diagnostic for NMO. |
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