AFP Tumor Marker
| Sunquest Code: | AFP | ||
| Epic Code: | LAB559 | Epic Name: | AFP Tumor Marker |
| Methodology: | Chemiluminescent immunoassay
St. Joseph: Chemiluminescent microparticle assay |
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| Turnaround Time: | Performed and reported 24 hours/day. | ||
| Special Instructions: | This test is used as a tumor marker, not for neural tube defect screening. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.5 mL |
| Minimum\Peds Volume: | 0.6 mL |
| Container: | Red or gold (gel), St Johns/St Joseph/Woodwinds - Red (no gel) [Alternate Containers: Red (no gel), St Johns/St Joseph/Woodwinds-Green (lithium heparin, no gel)] |
| Causes for Rejection: | Gross hemolysis |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 1.25 mL; 0.2 mL minimum (SJO: 0.5 mL minimum). Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. Alternatively, ship on dry ice. |
| Stability: | 8 hours at room temperature; 48 hours refrigerated; indefinitely frozen |
| Test Performed at or Referral Lab | Chemistry (UMMC-East Bank, St. Joseph's) |
Interpretive
| Reference Range: | 1 year and up <8.1 ug/L.
Reference values for adult non-pregnant female only, fetal production of AFP elevates values in pregnant women. Ranges for newborns are not available, but concentrations over 100,000 ug/L have been reported in normal newborns. Values rapidly decline to <100 ug/L by 5 months and reach adult levels by 1 year. The ADVIA Centaur AFP method is used. Results obtained with different assay methods or kits cannot be used interchangeably. St. Joseph: 1 year and up: <8.6 ng/mL |
| Use: | Aids in the differential diagnosis and therapeutic monitoring of germinal neoplasms of the testis, ovary, retroperitoneum, mediastinum, and heptocellular carcinoma. Seminomas do not produce AFP. |
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