AFP Tumor Marker

Sunquest Code:AFP  
Epic Code:LAB559Epic Name:AFP Tumor Marker
Methodology:Chemiluminescent immunoassay
St. Joseph: Chemiluminescent microparticle assay
Turnaround Time:Performed and reported 24 hours/day.
Special Instructions:This test is used as a tumor marker, not for neural tube defect screening.

Collection Instructions

Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL
Container:Red or gold (gel), St Johns/St Joseph/Woodwinds - Red (no gel)
[Alternate Containers: Red (no gel), St Johns/St Joseph/Woodwinds-Green (lithium heparin, no gel)]
Causes for Rejection:Gross hemolysis

Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1.25 mL; 0.2 mL minimum (SJO: 0.5 mL minimum). Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature. Alternatively, ship on dry ice.
Stability:8 hours at room temperature; 48 hours refrigerated; indefinitely frozen
Test Performed at or Referral Lab Chemistry  (UMMC-East Bank, St. Joseph's)


Reference Range:1 year and up <8.1 ug/L.
Reference values for adult non-pregnant female only, fetal production of AFP elevates values in pregnant women. Ranges for newborns are not available, but concentrations over 100,000 ug/L have been reported in normal newborns. Values rapidly decline to <100 ug/L by 5 months and reach adult levels by 1 year. The ADVIA Centaur AFP method is used. Results obtained with different assay methods or kits cannot be used interchangeably.

St. Joseph: 1 year and up: <8.6 ng/mL
Use:Aids in the differential diagnosis and therapeutic monitoring of germinal neoplasms of the testis, ovary, retroperitoneum, mediastinum, and heptocellular carcinoma. Seminomas do not produce AFP.

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