Renin Activity, Plasma to Mayo - Pediatric

Abbrev Code:PRAP   
Order Code:LAB6544Order Name:Renin Plasma
Synonyms:Plasma Renin Activity LC/MS/MS-Pediatric
Methodology:Liquid chromatography/Tandem mass spectrometry (LC-MS/MS)
CPT Codes: 84244 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 2-5 days.
Special Instructions:Pediatric patients only. For adult testing see Renin Activity to ARUP.

This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared by the U.S. Food and Drug Administration.

Collection Instructions

Optimal Volume:4 mL
Minimum\Peds Volume:2.6 mL Does not permit repeat analysis.
Container:Purple (EDTA) on ICE
Collection Instructions:

1.     Draw blood in a chilled syringe from a patient in a seated position; place specimen in a chilled, lavender top (EDTA) tube and mix.

2.     Alternatively, draw blood directly in a chilled, lavender top (EDTA) tube.

3.     Immediately place EDTA tube into an ice-water bath until thoroughly cooled.

4.     Refrigerate specimen during centrifugation and immediately transfer plasma to a plastic vial. (If a refrigerated centrifuge is unavailable, chill the centrifuge carriers. Centrifuge specimen for ≤ 5 minutes, then promptly transfer.


Causes for Rejection:Gross hemolysis. Non-frozen specimens.

Processing and Shipping

Specimen Processing:Separate plasma from cells and freeze immediately. Centrifuge and aliquot 2 mL, 1.15 mL minimum.
Shipping Instructions:Ship on dry ice.
Stability:14 days frozen.
Test Performed at or Referral Lab Lab Sendouts  (Mayo)
Referral Lab number:PRA


Reference Range:
0-2 years 1.4-7.8 ng/mL/hour
3-5 years 1.5-3.5 ng/mL/hour
6-8 years 0.8-2.0 ng/mL/hour
9-11 years 0.9-2.9 ng/mL/hour
12-17 years 1.2-2.4 ng/mL/hour
*Mean data are not standardized as to time of day or diet. Infants were supine, children sitting.
Use:Investigation of primary aldosteronism (e.g. adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter's syndrome).

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