T-Cell Receptor Excision Circles

Abbrev Code:TRECS   
Order Code:LAB6352Order Name:T-Cell Receptor Excision Circles
Synonyms:T Cell; Trec, B
Methodology:Real-time quantitative polymerase chain reaction (PCR)
CPT Codes: 81479 x1, 81479 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Thur only; results are reported within 9 days
Special Instructions:Ordering physician's name and phone number are required.

A completed TREC Assay Patient Information form must accompany each specimen. See Associated Links.

This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared by the U.S. Food and Drug Administration.

Associated Links:

TREC Assay Patient Information Form

Collection Instructions

Specimen:Whole blood. Do not collect with a butterfly needle.
Optimal Volume:Adults: 10 mL
Preferred Pediatrics:
>1 y: 5 mL
≤1 y: 3 mL
Minimum\Peds Volume:Adults: 10 mL
Pediatrics: 1 mL
Container:Purple (EDTA)
Collection Instructions:Do not collect specimen using a butterfly needle.

Collect and package specimen as close to shipping time as possible.

For serial monitoring, it is recommended to perform specimen collection at the same time of day, if possible.
Causes for Rejection:Gross hemolysis or lipemia.

Processing and Shipping

Specimen Processing:Send whole blood specimen in original tube. Do not aliquot/pour-off. Store at room temperature.
Shipping Instructions:It is recommended that specimens arrive within 24 hours of collection. Specimens must be received in the laboratory on weekdays and by 4 p.m. on Friday. Samples arriving over the weekend or on observed holidays may be canceled. Ship at room temperature.
Stability:48 hours at room temperature
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:TRECS


Reference Range:The appropriate age-related reference values will be provided on the report.
Use:This assay is useful for evaluating thymic output, and for longitudinal assessment of thymic function.

Measuring T-cell output or reconstitution (thymopoiesis) following hematopoietic cell transplantation or highly active antiretroviral therapy.

Evaluating thymic function in patients with cellular or combined inborn errors of immunity (formerly primary immunodeficiencies), or receiving immunotherapy or cancer vaccines.

Assessing T-cell recovery following thymus transplants for DiGeorge syndrome.

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