Myeloperoxidase and Proteinase 3 Panel

Abbrev Code:VASPAN   
Order Code:LAB6360Order Name:Myeloperoxidase and Proteinase 3 Panel
Synonyms:Myeloperoxidase (MPO) Antibody, IgG; Proteinase 3 (PR3) Antibody, IgG; Anti-Neutrophil Cytoplasmic Antibodies; Autoantibodies
Methodology:Fluorescent enzyme immunoassay
CPT Codes: 83876 x1, 83516 x1
Test Includes:Test orders codes: MPOIGG and PR3IGG. When possible, order specific individual antibodies if entire panel is not needed.
Turnaround Time:Performed twice weekly; results are reported within 4 days.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:0.9 mL
Container:Red or gold (gel)
Alternate Containers: Green (lithium heparin, gel), Purple (EDTA), Red (no gel)
Causes for Rejection:Gross hemolysis

Processing and Shipping

Specimen Processing:Centrifuge ASAP and aliquot 1 mL, 0.35 mL minimum. Store in refrigerator up to 14 days.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab UM Specialty Core/Prot/Endo (Phadia ELiA G) 


Reference Range:
Component Reference Interval
Myeloperoxidase (MPO)
Antibody IgG
Negative: Less than 3.5 U/mL
Positive: 5.0 U/mL or greater
Proteinase 3 (PRA)
Antibody IgG
Negative: Less than 2.0 U/mL
Positive: Greater than 3.0 U/mL
Use:Aids in the diagnosis of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides: Microscopic Polyangiitis (MPA), Necrotising Gomerulonephritis, Churg-Strauss Syndrome and Wegener's Granulomatosis.

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