Bruton Tyrosine Kinase (BTK) Genotype and Protein Analysis, Full Gene Sequence and flow Cytometry

Abbrev Code:MMMISC   
Order Code:LAB4909Order Name:Laboratory Miscellaneous Order
Methodology:Flow cytometry
CPT Codes: 88184 x1, 81406 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Thur; results are reported within 30 days.
Special Instructions:Bone marrow transplants will interfere with testing. Transfusions will interfere with testing for up to 4 to 6 weeks. It is recommended that the specimen arrive within 24 hours of collection.
Associated Links:

Genetic Testing Consent Form

Collection Instructions

Optimal Volume:5 mL
Minimum\Peds Volume:2 mL (pediatric)
Container:Purple (EDTA)
Collection Instructions:Two separate EDTA specimens and the patient information sheet are required.

Processing and Shipping

Specimen Processing:Whole blood. Do not process. Specimen must arrive less than 72 hours after collection.
Label one EDTA tube with BTKSP
Label second EDTA tube with BTK
Shipping Instructions:Ship same day; must arrive within 72 hours of collection.  
  • Ship BTKSP at refrigerated (preferred) or room temp.
  • Ship BTK only at room temperature, Mon-Thurs only.
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:BTKFP (89742)


Use:Preferred test for confirming a diagnosis of x-linked agammaglobulinemia (XLA) in males with a history of recurrent sinopulmonary infections, profound hypogammaglobulinemia, and <1% peripheral B cells.

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