Soluble Mesothelin Related Peptides

Abbrev Code:ARMISC   
Order Code:LAB4909Order Name:Send Outs Misc Test
Methodology:Enzyme-linked immunosorbent assay
CPT Codes: 86316 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-8 days.
Special Instructions:Because MESOMARK® is a test approved by the FDA as a Humanitarian Use Device, testing should be ordered using the following procedure(s):
  1. The ordering physician must register with the Institutional Review Board (IRB) for MESOMARK® testing. Go to to obtain IRB certification online.
  2. The test should be ordered using the ARUP requisition form. The full name of the ordering physician must be included on the ARUP form to ensure timely testing of the specimen. Specimens submitted with incomplete information may delay specimen testing.
  3. Physicians are instructed as follows: ARUP does not accept specimens directly from physician offices. ARUP only accepts specimens from established clients. To send a specimen to ARUP, contact your local hospital/reference lab to determine if they are an ARUP client and can send the specimen. If they cannot send the specimens to ARUP, contact ARUP Client Services at (800) 522-2787 to find an ARUP client in your area.
  4. Forms and information about MESOMARK® testing, and IRB registration, may be accessed at
  5. ARUP will receive specimens via usual shipping routes, from designated clients. When the specimen arrives, with an accompanying requisition, the physician's full name will be logged in, if present. If the ordering physician's full name is not present, the specimen is placed on EXCEPT after evaluation by the Special Chemistry department. The Special Chemistry lab will then contact Fujirebio Diagnostics, Inc. (FDI), who will then contact the physician for certification. FDI will then notify ARUP in Special Chemistry of completed certification. Special Chemistry will proceed with testing after certification is completed by the physician.

Collection Instructions

Optimal Volume:1 mL
Minimum\Peds Volume:0.4 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)

Processing and Shipping

Specimen Processing:Allow specimen to clot completely before centrifuging. Aliquot 0.2 mL, 0.1 mL minimum. Store frozen.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:81284


Use:MESOMARK® is an enzyme-linked immunosorbent assay for the quantitative measurement of soluble mesothelin related peptides (SMRP) in serum. Measurement of SMRP may aid in the management of patients diagnosed with epithelioid or biphasic mesothelioma. Epidemiologic studies have established exposure to asbestos fibers as the primary cause of malignant mesothelioma. Results obtained with different assay methods or kits cannot be used interchangeably. Results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.

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