Mannose Binding Lectin


Abbrev Code:MANLEC   
Order Code:LAB6679Order Name:Mannose Binding Lectin
Methodology:ELISA
CPT Codes: 83520 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-8 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.6 mL
Container:Red or gold (gel)
Alternate Containers: Green (lithium heparin, gel), Red (no gel)
Causes for Rejection:Specimens collected in EDTA or citrate. Contaminated or heat-inactivated specimens, Room temperature or refrigerated specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection 1 mL, 0.2 mL minimum.
CRITICAL FROZEN: Separate specimens must be submitted when multiple tests are ordered.
Shipping Instructions:Ship on dry ice.
Stability:1 year frozen
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:51692


Interpretive

Reference Range:Greater than 50 ng/mL.
Use:Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B and in autoimmune disorders including recurrent spontaneous abortion and systemic erythematosus.


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