ADAMTS13 Activity with Reflex to Inhibitor and Antibody

Abbrev Code:ADAMEV   
Order Code:LAB6839Order Name:ADAMTS13 Activity W Reflex to Inhib ABY
Synonyms:ADAMTS Evaluation; VWF Cleaving Protease
Methodology:See individual test codes
CPT Codes: 85397 x1, 85335 x1, 83520 x1
Test Includes:ADAMTS13 activity with reflex to inhibitor and antibody is a reflexive testing algorithm. ADAMTS13 Activity is always performed. If activity is less than or equal to 30%, the inhibitor assay is performed. If the inhibitor is less than or equal to 0.7 Inhibitor Units, testing for ADAMTS13 is performed.
Turnaround Time:Specimens are sent to the reference laboratory Mon-Fri; results are reported within 2-10 days.
Special Instructions:Send platelet-poor plasma for testing. See Specimen Collection and Processing for Special Coagulation Specimens Associated Link.
Associated Links:

Specimen Collection and Processing for Coagulation Specimens

Collection Instructions

Optimal Volume:2.7 mL (in 3 mL tube) - filled to fill line on the tube
Minimum\Peds Volume:1.8 mL (in 2 mL tube) - filled to fill line on the tube
Container:Blue Na Citrate, 3.2% - fill to fill line on tube
Causes for Rejection:Over-filled or under-filled tubes. Clotted specimens or specimens collected in the incorrect tube.
Hemolyzed specimens will be run with a disclaimer.

Processing and Shipping

Specimen Processing:See Special Coagulation processing instructions. Send three 0.5 mL aliquots, two 0.4 mL aliquots minimum. Store in freezer.
Shipping Instructions:Ship on dry ice.
Stability:Up to 7 days at room temperature or refrigerated; indefinitely frozen (preferred).
Test Performed at or Referral Lab Lab Sendouts  (Versiti)
Referral Lab number:1295


Reference Range:

ADAMTS13 Activity

Greater than or equal to 67%

ADAMTS13 Inhibitor

Less than or equal to 0.4 Inhibitor Units

ADAMTS13 Antibody

Less than or equal to 18 Arbitrary Units



Use:Diagnosis of congenital or idiopathic thrombotic thrombocytopenic purpura (TTP).

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