Protein S Antigen, Total

Abbrev Code:ARMISC   
Order Code:LAB4909Order Name:Sendout Misc Test
Order Instructions:Do not order if individual has been on warfarin therapy in the previous 2-4 weeks.
Methodology:Microlatex Particle - Mediated Immunoassay
CPT Codes: 85305 x1, 85305 x1
Turnaround Time:Specimen sent to reference laboratory Mon-Fri; results reported within 3 days.

This test uses an in vitro diagnostic (IVD) that has been cleared or approved by the FDA.

Associated Links:

Specimen Collection and Processing for Coagulation Specimens

Collection Instructions

Optimal Volume:Three 2.7 mL (in 3 mL tube) - fill to fill line on the tube
Minimum\Peds Volume:Two 2.7 mL (in 3 mL tube) - fill to fill line on the tube
Container:Blue Na Citrate, 3.2% - fill to fill line on tube
Collection Instructions:Patient should be off warfarin for at least 2 weeks before drawing sample.
Causes for Rejection:Overfilled or underfilled tubes. Specimen other than citrated plasma. Clotted or hemolyzed specimens. Refrigerated specimens.

Processing and Shipping

Specimen Processing:See link to Specimen Collection and Processing of Coagulation Specimens for platelet-poor plasma. Transfer 1.5 mL, minimum of 1 mL, platelet-poor plasma to an ARUP Standard Transport tube. Store frozen.
Shipping Instructions:Ship frozen.
Stability:4 hours room temperature; 3 months frozen at -20°C; 6 months frozen at -70°C
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:0030112


Reference Range:
Age Male Female
1-4 d 12-60% 12-60%
5-29 d 22-78% 22-78%
30-89 d 33-93% 33-93%
90-179 d 54-118% 54-118%
180-364 d 55-119% 55-119%
1-5 y 54-118% 54-118%
6-10 y 41-114% 41-114%
11 y & older 84-134% 63-126%
Limitations:Patients on warfarin may have decreased protein S values. Patients should be off warfarin therapy for two weeks for accurate measurement of protein S.
Use:Not recommended for detecting protein S deficiency; preferred test is Protein S Free, Antigen (LAB492). Use to subtype deficiency in known protein S-deficient individuals in combination with Protein S Free, Antigen, or Protein S, Functional (Miscellaneous to ARUP test ID 0030114). 

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