Human Immunodeficiency Virus Type 1 (HIV-1) Trofile Co-Receptor Tropism
| Abbrev Code: | TROTRIP | ||
| Order Code: | LAB6664 | Order Name: | Trofile Co-Receptor Tropism |
| Synonyms: | Tropism | ||
| Methodology: | Recombinant virus, single replication | ||
| CPT Codes: | 87999 x1, 87999 x1 | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Fri; results are reported within 16-23 days. | ||
| Special Instructions: | Provide the patient's HIV 1 Viral Load.
Procedure should be used for patients with documented HIV-1 infection and viral loads greater than 1000 copies/mL. |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 6.2 mL |
| Container: | Purple (EDTA) |
| Causes for Rejection: | Thawed specimens. |
Processing and Shipping
| Specimen Processing: | Within 6 hours of collection, centrifuge and aliquot 3 mL plasma. Freeze immediately. |
| Shipping Instructions: | Ship on dry ice. CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. |
| Stability: | 2 weeks frozen at -20. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 3001246 |
Interpretive
| Reference Range: | By report. |
| Use: |
For patients with HIV-1 viral loads ≥ 1000 copies/mL.
The US Department of Health and Human Services (DHHS) and the Infectious Diseases Society of America (IDSA) guidelines recommend that a coreceptor tropism test be performed whenever the use of CCR5 inhibitor is being considered. Coreceptor tropism testing might also be considered for patients who exhibit virologic failure on a CCR5 inhibitor. |
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