Alpha-1-Antitrypsin Proteotype S/Z, Serum

Abbrev Code:MMMISC   
Order Code:LAB4909Order Name:Laboratory Miscellaneous Order
Synonyms:Alpha 1 Antitrypsin Deficiency
Methodology:Liquid chromatography-Tandem mass spectrometry; Nephelometry; Isoelectric focusing
CPT Codes: 82103 x1, 82454 x1, 82104 x1
Test Includes:A1AT protein quantitation (serum) and Proteotyping for Z and S alleles using LC-MS/MS; if discordant, reflex to Phenotyping by isoelectric focusing with an additional charge. 
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 7-14 days.
Associated Links:

Alpha-1 Antitrypsin Testing Algorithm

Collection Instructions

Optimal Volume:2.5 mL
Minimum\Peds Volume:1.2 mL
Container:Red (no gel)
Alternate Containers: Red or gold (gel)
Causes for Rejection:Grossly lipemic specimens.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1.25 mL, 0.5 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Samples are stable for 28 days at room temperature, refrigerated or frozen.
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:A1ALC


Reference Range:Alpha-1-Antitrypsin: 100-190 mg/dL
Alpha-1-Antitrypsin Proteotype: Negative for S and Z phenotype (Non S Non Z)
Use:Determining the specific proteotype for prognosis and genetic counseling for patients with alpha-1-antitrypsin deficiency.

Click HERE to Report test errors or omissions.
*If no email program is associated with this computer, please contact:
[email protected] for TestID: 5435"