Alpha-1-Antitrypsin Proteotype S/Z, Serum
| Abbrev Code: | MMMISC | ||
| Order Code: | LAB4909 | Order Name: | Laboratory Miscellaneous Order |
| Synonyms: | Alpha 1 Antitrypsin Deficiency | ||
| Methodology: | Liquid chromatography-Tandem mass spectrometry; Nephelometry; Isoelectric focusing | ||
| CPT Codes: | 82103 x1, 82454 x1, 82104 x1 | ||
| Test Includes: | A1AT protein quantitation (serum) and Proteotyping for Z and S alleles using LC-MS/MS; if discordant, reflex to Phenotyping by isoelectric focusing with an additional charge. | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Fri; results are reported within 7-14 days. | ||
| Associated Links: | |||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.5 mL |
| Minimum\Peds Volume: | 1.2 mL |
| Container: | Red (no gel) Alternate Containers: Red or gold (gel) |
| Causes for Rejection: | Grossly lipemic specimens. |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 1.25 mL, 0.5 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | Samples are stable for 28 days at room temperature, refrigerated or frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (Mayo Medical Laboratories) |
| Referral Lab number: | A1ALC |
Interpretive
| Reference Range: | Alpha-1-Antitrypsin: 100-190 mg/dL
Alpha-1-Antitrypsin Proteotype: Negative for S and Z phenotype (Non S Non Z) |
| Use: | Determining the specific proteotype for prognosis and genetic counseling for patients with alpha-1-antitrypsin deficiency. |
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