Heparin-Dependent Platelet Antibody (SRA) Unfractionated
Abbrev Code: | HDPA | ||
Order Code: | LAB6539 | Order Name: | Heparin Dependent PLT Aby SRA |
Synonyms: | Serotonin Release Assay; SRA; SRA-Porcine Heparin | ||
Methodology: | Serotonin release assay | ||
CPT Codes: | 86022 x1 | ||
Turnaround Time: | Specimens are sent to reference laboratory Mon-Fri; results are reported within 1-3 days. |
Collection Instructions
Specimen: | Blood |
Optimal Volume: | 10 mL |
Minimum\Peds Volume: | 2.2 mL |
Container: | Red or gold (gel) Alternate Containers: Red (no gel) |
Processing and Shipping
Specimen Processing: | Centrifuge and aliquot 5 mL, 1 mL minimum. Store in refrigerator. |
Shipping Instructions: | Ship same day at refrigerated temperature or on dry ice. |
Stability: | 7 days at refrigerated temperatures, or freeze for longer storage. |
Test Performed at or Referral Lab | Lab Sendouts (Versiti) |
Referral Lab number: | 5508 |
Interpretive
Reference Range: | A positive result requires greater than or equal to 20% release of serotonin with low dose heparin AND less than 20% release in the presence of a high concentration of heparin. Results are interpreted as negative, borderline positive or positive. |
Limitations: | The presence of "non-drug" antibodies reactive with platelets (e.g., HLA Class I, autoantibodies, platelet-specific antibodies) in the patient's serum can induce heparin independent release of serotonin in the SRA. Testing with Lovenox® (Enoxaparin) versus unfractionated heparin has not been validated as a useful guide to clinical management. |
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