Heparin-Dependent Platelet Antibody (SRA) Unfractionated

Abbrev Code:HDPA   
Order Code:LAB6539Order Name:Heparin Dependent PLT Aby SRA
Synonyms:Serotonin Release Assay; SRA; SRA-Porcine Heparin
Methodology:Serotonin release assay
CPT Codes: 86022 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 1-3 days.

Collection Instructions

Optimal Volume:10 mL
Minimum\Peds Volume:2.2 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)

Processing and Shipping

Specimen Processing:Centrifuge and aliquot 5 mL, 1 mL minimum. Store in refrigerator.
Shipping Instructions:Ship same day at refrigerated temperature or on dry ice.
Stability:7 days at refrigerated temperatures, or freeze for longer storage.
Test Performed at or Referral Lab Lab Sendouts  (Versiti)
Referral Lab number:5508


Reference Range:A positive result requires greater than or equal to 20% release of serotonin with low dose heparin AND less than 20% release in the presence of a high concentration of heparin. Results are interpreted as negative, borderline positive or positive.
Limitations:The presence of "non-drug" antibodies reactive with platelets (e.g., HLA Class I, autoantibodies, platelet-specific antibodies) in the patient's serum can induce heparin independent release of serotonin in the SRA. Testing with Lovenox® (Enoxaparin) versus unfractionated heparin has not been validated as a useful guide to clinical management.

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