Heparin-Dependent Platelet Antibody (SRA) Unfractionated
| Sunquest Code: | HDPA | ||
| Epic Code: | LAB6539 | Epic Name: | Heparin Dependent PLT Aby SRA |
| Synonyms: | Serotonin Release Assay; SRA; SRA-Porcine Heparin | ||
| Methodology: | Serotonin release assay | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Fri; results are reported within 1-3 days. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 10 mL |
| Minimum\Peds Volume: | 2.2 mL |
| Container: | Red or gold (gel) [Alternate Containers: Red (no gel)] |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 5 mL, 1 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship same day at refrigerated temperature or on dry ice. |
| Stability: | 7 days at refrigerated temperatures, or freeze for longer storage. |
| Test Performed at or Referral Lab | Lab Sendouts (Versiti) |
| Referral Lab number: | 5508 |
Interpretive
| Reference Range: | A positive result requires greater than or equal to 20% release of serotonin with low dose heparin AND less than 20% release in the presence of a high concentration of heparin. Results are interpreted as negative, borderline positive or positive. |
| Limitations: | The presence of "non-drug" antibodies reactive with platelets (e.g., HLA Class I, autoantibodies, platelet-specific antibodies) in the patient's serum can induce heparin independent release of serotonin in the SRA. Testing with Lovenox® (Enoxaparin) versus unfractionated heparin has not been validated as a useful guide to clinical management. |
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