Rapid Plasma Reagin Titer
| Abbrev Code: | RPRTAB | ||
| Order Code: | PLAB306 | Order Name: | Rapid Plasma Reagin Titer |
| Order Instructions: | Order TREPT first. This test will be non-orderable by the provider. The RPRAB will reflex to this test. | ||
| Synonyms: | Syphilis Screening Test; RPR; VDRL; Prenatal Screen | ||
| Methodology: | Semi-quantitative charcoal agglutination | ||
| CPT Codes: | 86593 x1 | ||
| Turnaround Time: | Performed three times per week; results are reported the next day. | ||
| Associated Links: | |||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 6 mL |
| Minimum\Peds Volume: | 4.2 mL |
| Container: | Red or gold (gel) Alternate Containers: Red (no gel) |
| Causes for Rejection: | Hemolysis |
| Contraindications: | This test (RPRTAB) is not used to test CSF specimens; see VDRL, Cerebrospinal Fluid. |
Processing and Shipping
| Specimen Processing: | Centrifuge and leave sample in serum separator tube (preferred). Alternatively, aliquot 3 mL, 2 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | 7 days at refrigerated temperature; for longer storage freeze. |
| Test Performed at or Referral Lab | UM Specialty Core/Prot/Endo (Liaison D) |
Interpretive
| Reference Range: | Negative |
| Use: | The quantitative RPR test is performed on patients with syphilis, a fourfold rise in titer in a repeat specimen may suggest infection, a reinfection, or a treatment failure. A fourfold decrease in the titer following treatment for early syphilis usually indicates that therapy was adequate. Unusually high RPR titers can be seen with concurrent human immunodeficiency virus type 1 infection. Unusually high false-positive titers may also be seen in patients with lymphomas. |
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