Rapid Plasma Reagin Titer

Abbrev Code:RPRTAB   
Order Code:PLAB306Order Name:Rapid Plasma Reagin Titer
Order Instructions:Order TREPT first. This test will be non-orderable by the provider. The RPRAB will reflex to this test.
Synonyms:Syphilis Screening Test; RPR; VDRL; Prenatal Screen
Methodology:Semi-quantitative charcoal agglutination
CPT Codes: 86593 x1
Turnaround Time:Performed three times per week; results are reported the next day.
Associated Links:

Syphilis Serology Algorithm

Collection Instructions

Optimal Volume:6 mL
Minimum\Peds Volume:4.2 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Hemolysis
Contraindications:This test (RPRTAB) is not used to test CSF specimens; see VDRL, Cerebrospinal Fluid.

Processing and Shipping

Specimen Processing:Centrifuge and leave sample in serum separator tube (preferred). Alternatively, aliquot 3 mL, 2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:7 days at refrigerated temperature; for longer storage freeze.
Test Performed at or Referral Lab UM Specialty Core/Prot/Endo (Liaison D) 


Reference Range:Negative
Use:The quantitative RPR test is performed on patients with syphilis, a fourfold rise in titer in a repeat specimen may suggest infection, a reinfection, or a treatment failure. A fourfold decrease in the titer following treatment for early syphilis usually indicates that therapy was adequate. Unusually high RPR titers can be seen with concurrent human immunodeficiency virus type 1 infection. Unusually high false-positive titers may also be seen in patients with lymphomas.

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