Genetic Renal Panel to MORL
| Abbrev Code: | XMISC | ||
| Order Code: | LAB4909 | Order Name: | Laboratory Miscellaneous Order |
| Synonyms: | Hemolytic Uremic Syndrome; aHUS; Atypical Hemolytic Uremic Syndrome; Complement Kidney Genes; Thrombotic Microangiopathies; Complement Nephropathy Gene Analysis | ||
| Methodology: | Next generation sequencing and Multiple Ligation Probe Amplification | ||
| CPT Codes: | 81479 x1, 81405 x1 | ||
| Turnaround Time: | Specimens are sent to the reference laboratory Mon-Thurs; results are reported within 3 weeks | ||
| Special Instructions: | A completed requisition must accompany each specimen. See associated links. Samples are accepted Mon-Friday only. Do not send samples for weekend delivery or the day before a holiday. | ||
| Associated Links: | |||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 10 mL adult or 4 mL for children under 4 years of age |
| Minimum\Peds Volume: | 8 mL adult; 3 mL for children under 4 years of age. |
| Container: | Purple (EDTA) |
| Causes for Rejection: | Frozen or clotted specimen, incorrect anticoagulant, specimen more than 7 days old. |
Processing and Shipping
| Specimen Processing: | Whole blood Do not process. Store at room temperature or if shipping is delayed refrigerate. |
| Shipping Instructions: | Ship overnight at room temperature. Protect from temperature extremes. Do not freeze. |
| Stability: | 1 week refrigerated |
| Test Performed at or Referral Lab | Lab Sendouts (University Iowa Molecular Otolaryngology & Renal Research Laboratories) |
| Referral Lab number: | GRP08 |
Interpretive
| Reference Range: | By report. |
| Use: |
Screens 12 genes (CFH, CFI, MCP, CFB, CFHR5, C3, THBD, ADAMTS13, DGKE, MMACAHC, G6PD and PLG) known to be associated with the thrombotic microangiopathies: Hemolytic Uremic Syndrome, atypical Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura. The panel utilizes custom-targeted sequence capture for DNA enrichment followed by massively parallel DNA sequencing. Multiple Ligation Probe Amplification of the CFH-CFHR5 genomic region is also performed as part of this panel.
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