Copper, Liver Tissue
| Abbrev Code: | CPLVTS | ||
| Order Code: | LAB6764 | Order Name: | Copper, Liver Tissue |
| Methodology: | Inductively coupled plasma/Mass spectrometry | ||
| CPT Codes: | 82525 x1 | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported within 2-6 days. | ||
| Compliance: | For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes. |
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Collection Instructions
| Specimen: | Liver tissue |
| Optimal Volume: | 2 cm (collected with a 18-gauge needle) |
| Minimum\Peds Volume: | 1 cm (collected with an 18 gauge needle) |
| Container: | Metal-free container, Tissue |
| Collection Instructions: | Tissue can be fresh, paraffin-embedded or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container, such as a royal blue (no additive). |
| Causes for Rejection: | Specimens less than 0.25 mg (dry weight). Paraffin blocks that have been processed with Hollandes or other copper-containing stain. |
Processing and Shipping
| Specimen Processing: | Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | Stability: Paraffin block, preserved (formalin) or dried: Indefinitely at room temperature, refrigerated or frozen. Fresh tissue: 1 week refrigerated; indefinitely frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 20694 |
Interpretive
| Reference Range: | 15-55 ug/g of tissue |
| Use: | Hepatic copper concentrations approach or exceed 250 ug/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution. |
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