N-Methylhistamine, Random Urine
| Sunquest Code: | NMHR | ||
| Epic Code: | LAB8221 | Epic Name: | N-Methylhistamine Random Urine |
| Methodology: | Liquid chromatography/Tandem mass spectrometry (LC-MS/MS); Enzymatic colorimetric assay | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Fri; results are reported within 3-7 days. | ||
| Special Instructions: | This test is for random urine collection only. For timed urine see N-Methylhistamine, 24 hour Urine.
Patients with chronic mast cell activation often have chronically elevated N-Methylhistamine (NMH) levels and will sometimes have intermittent NMH elevations. In these cases, a 24 hour urine collection is preferred. |
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| Compliance: | This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared by the U.S. Food and Drug Administration. |
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Collection Instructions
| Specimen: | Urine, random |
| Optimal Volume: | Submit entire collection; analysis requires 3 mL |
| Minimum\Peds Volume: | 3 mL |
| Container: | Plastic leakproof container, sterile |
| Collection Instructions: | Collect a random urine specimen within a few hours of symptom onset. |
| Patient Preparation: | Patient must not be taking monoamine oxidase inhibitors (MAOIs) or aminoguanidine as these medications increase N-methylhistamine (NMH) levels. |
| Causes for Rejection: | Preserved urine; timed collection. |
Processing and Shipping
| Specimen Processing: | Aliquot 5 mL, 3 mL minimum. Store refrigerated. |
| Shipping Instructions: | Ship refrigerated. |
| Stability: | 28 days room temperature, refrigerated (preferred) and frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (Mayo Medical Laboratories) |
| Referral Lab number: | NMHR |
Interpretive
| Reference Range: |
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| Use: | Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions. Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis. |
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