Alpha Defensin, Lateral Flow Assay, Synovial Fluid
Abbrev Code: | ALDEF | ||
Order Code: | LAB6665 | Order Name: | Alpha Defensin LFA Synovial Fluid |
Synonyms: | Synovasure; Periprosthetic Joint Infection (PJI) | ||
Methodology: | Lateral Flow Assay (LFA) | ||
CPT Codes: | 83518 x1, 83518 x1 | ||
Turnaround Time: | Specimens are sent to the reference laboratory daily; testing is performed Mon, Fri, Sun and results are reported within 1 day. | ||
Special Instructions: | This test should only be used for patients with total joint prothesis. If specimen is grossly hemolyzed, see Synovasure, Synovial Fluid ELISA (bloody or hemolyzed specimen that is inadequate for LFA assay) Lab Guide page. | ||
Associated Links: | Synovasure Request Form, See Lab Guide page: Synovasure, Synovial Fluid - ELISA (bloody or hemolyzed specimen that is inadequate for LFA assay) [Lab Guide page 7003] |
Collection Instructions
Specimen: | Synovial Fluid |
Optimal Volume: | 1 mL |
Minimum\Peds Volume: | 0.1 mL |
Container: | Plastic leakproof container, sterile Alternate Containers: Red (no gel) |
Collection Instructions: | Specimen source and type of joint are required. If not obtained from a prosthetic joint, testing will be cancelled. |
Causes for Rejection: | If not obtained from a prosthetic joint, testing will be cancelled. Grossly hemolyzed. |
Processing and Shipping
Specimen Processing: | Do not process. Transport specimen in the original collection container. Indicate specific collection site on collection container. Separate specimens must be submitted when multiple tests are ordered. Store in refrigerator. |
Shipping Instructions: | Ship at refrigerated temperature. |
Stability: | 7 days refrigerated. |
Test Performed at or Referral Lab | Lab Sendouts (Mayo Medical Laboratories) |
Referral Lab number: | ALDEF |
Interpretive
Reference Range: |
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Limitations: |
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Use: | Alpha defensin in synovial fluid detected, suggesting presence of prosthetic joint infection. Additional microbiologic studies (e.g., culture, molecular detection) are recommended.
Detection of alpha defensins 1-3, human host response proteins, in synovial fluid of adults with a total joint replacement who are being evaluated for revision surgery. This test is not intended to be used to determine timing for reimplantation in 2-stage procedures. |
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