Histoplasma capsulatum Antigen, Non-Blood

Abbrev Code:HISTPU   
Order Code:LAB6465Order Name:Histoplasma Capsulatum Agn NonBlood
Order Instructions:See HISABY for blood specimens.
Methodology:Enzyme immunoassay
CPT Codes: 87385 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Thur; results are reported within 2-3 days.
Special Instructions:Patient should not have more than one urine histoplasma per 24 hours.
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Urine Collection Procedure

Collection Instructions

Specimen:Urine, CSF, Fluid (BAL preferred)
Optimal Volume:2 mL urine, CSF or fluid
Minimum\Peds Volume:0.5 mL urine or body fluid, 0.8 mL CSF
Container:Plastic leakproof container, sterile
Alternate Containers: Sterile tube, Plastic leakproof container, sterile
Causes for Rejection:Specimen too viscous to pipette. Tissue, sputum, bronchial brushing, stool, biopsy, tracheal or bone marrow aspirate. Sample stored in transport media, fixative or isolator tube.

Processing and Shipping

Specimen Processing:Aliquot 2 mL, 0.8 mL minimum CSF or 0.5 mL urine or other body fluid into a standard transport tube. Do not send sample in the original container. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:14 days at room temperature or refrigerated; and indefinitely frozen.
Test Performed at or Referral Lab Lab Sendouts  (MiraVista Diagnostics)
Referral Lab number:310


Reference Range:By report.
Limitations:Heterophile antibodies and rheumatoid factor can cause positive interference. Cross reactions due to closely related antigenic epitopes are seen in patients with blastomycosis, paracoccidiodomycosis and pencilliosis.
Use:Aid in the diagnosis of histoplasmosis by antigen detection. Measurement of antigen in urine offers the highest sensitivity for diagnosis of acute pulmonary or disseminated histoplasmosis. Testing bronchoalveolar lavage may improve the sensitivity for diagnosis of pulmonary histoplasmosis and CSF for diagnosis of meningitis. For monitoring therapy, testing both urine and serum offers the highest sensitivity.

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