Leukemia Lymphoma Evaluation, Cerebrospinal Fluid (CSF)

Abbrev Code:FLOLL   
Order Code:LAB501Order Name:Immunophenotyping/Flow Cytometry CSF (Epic)
Synonyms:Immunophenotpying CSF; Flow Cytometry CSF
Methodology:Multi-color immunofluorescence and flow cytometry
CPT Codes: 88185 x1, 88184 x1, 88187 x1, 88188 x1, 88189 x1
Test Includes:Combination of monoclonal antibodies chosen by pathologist for detection of malignant hematologic neoplasms, most commonly lymphoma or acute leukemia. Specific combination of monoclonal antibodies may include B lymphocyte markers including kappa and lambda/ HLA-DR, monocytic and/or myeloid markers, T lymphocyte markers, immature cell markers, or plasma cell markers. Results are interpreted by pathologist.
Turnaround Time:Performed Mon-Fri 08:00-17:00 and on Saturday before noon. Results are reported within 1-3 business days.
Special Instructions:Provide diagnosis, age, collection date and time, WBC and leukocyte differential. Deliver to the IFC laboratory within 4 hours of collection. Testing should not be performed on the first tube of collection. Contact the IFC laboratory at 612-273-5248 for further information. If testing is needed outside of scheduled hours, contact the hematopathology fellow.

This test was developed and its performance characteristics determined by University of Minnesota Medical Center, Fairview Clinical Laboratories. It has not been cleared or approved by the US Food and Drug Administration. FDA does not require this test to go through premarket FDA review. This test is used for clinical purposes and should not be regarded as investigational or for research. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) as qualified to perform high complexity clinical testing.

Collection Instructions

Optimal Volume:5 mL
Minimum\Peds Volume:3 mL (adult); 1 mL (pediatric)
Container:Sterile tube
Alternate Containers: Plastic leakproof container, sterile
Collection Instructions:
Sample must be received by the Immunophenotyping and Flow Cytometry laboratory within 4 hours of collection. Perform testing on the 3rd or 4th tube collected.  
Causes for Rejection:Samples received frozen, spun or too old to obtain accurate results (per pathologist decision).

Processing and Shipping

Specimen Processing:Do not process. Contact IFC laboratory with any questions prior to sending specimen at 612-273-5248. Testing should not be performed on the first tube of collection. Perform testing on the 3rd or 4th tube collected.
Shipping Instructions:Ship ASAP after collection. Must arrive at testing laboratory within 4 hours of collection.
Test Performed at or Referral Lab UM Flow Cytometry (W)  (UMMC East Bank)


Reference Range:By report.
Use:Diagnosis and clinical management of acute and chronic lymphoid and non-lymphoid leukemias. Monitor response to treatment and recurrent disease relapses. Define the type of purging procedure to be done prior to bone marrow reinfusion in autologous BMT. Identifies various types and subtypes of malignant lymphomas, such as B-cell, T-cell and true histiocytic. Differentiates lymphomas from other cancers and non-malignant processes.

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