Leukotriene E4, Random Urine
| Abbrev Code: | LTE4 | ||
| Order Code: | LAB6543 | Order Name: | Leukotriene E4 Urine |
| Order Instructions: | 24 Hour Urine preferred; see TLTE4, LAB8251 | ||
| Methodology: | Liquid chromatography/Tandem mass spectrometry (LC/MS/MS); Enzymatic colorimetric assay | ||
| CPT Codes: | 82542 x1, 82542 x1, 82570 x1, 82570 x1 | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Fri; results are reported within 2-6 days. | ||
| Compliance: | This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration. |
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Collection Instructions
| Specimen: | Urine, random |
| Optimal Volume: | Submit entire collection; analysis requires 1 mL |
| Minimum\Peds Volume: | 2 mL |
| Container: | Plastic leakproof container, sterile |
| Collection Instructions: | Collect a random urine specimen. No preservative preferred. |
Processing and Shipping
| Specimen Processing: | Aliquot 5 mL, 2 mL minimum. Store frozen. |
| Shipping Instructions: | Ship frozen. |
| Stability: | 24 hours at room temperature; 7 days refrigerated; 30 days frozen (preferred). |
| Test Performed at or Referral Lab | Lab Sendouts (Mayo Medical Laboratories) |
| Referral Lab number: | RLTE4 (Leukotrienne E4, Random Urine) |
Interpretive
| Use: | An aid to evaluate patients suspected of having systemic mastocytosis using random urine collections. Elevated urinary leukotriene E4 (LTE4) concentrations >104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4. |
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