Leukotriene E4, Urine
| Sunquest Code: | LTE4 | ||
| Epic Code: | LAB6543 | Epic Name: | Leukotriene E4 Urine |
| Methodology: | Liquid chromatography/Tandem mass spectrometry (LC/MS/MS); Enzymatic colorimetric assay | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Fri; results are reported within 2-6 days. | ||
| Compliance: | This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration. |
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Collection Instructions
| Specimen: | Urine, timed or random |
| Optimal Volume: | Submit entire collection; analysis requires 1 mL |
| Minimum\Peds Volume: | 1 mL |
| Container: | Plastic leakproof container, sterile (3 L plastic jug) |
| Collection Instructions: | Store specimen refrigerated during collection. |
Processing and Shipping
| Specimen Processing: | Aliquot 4 mL, 1 mL minimum. Store frozen. |
| Shipping Instructions: | Ship frozen. |
| Stability: | Stability: Refrigerated - 7 days; frozen - 30 days. |
| Test Performed at or Referral Lab | Lab Sendouts (Mayo Medical Laboratories) |
| Referral Lab number: | LTE4 |
Interpretive
| Use: | Elevated urinary leukotriene E4 (LTE4) concentrations >104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4. |
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