Leukotriene E4, Random Urine

Abbrev Code:LTE4   
Order Code:LAB6543Order Name:Leukotriene E4 Urine
Order Instructions:24 Hour Urine preferred; see TLTE4, LAB8251
Methodology:Liquid chromatography/Tandem mass spectrometry (LC/MS/MS); Enzymatic colorimetric assay
CPT Codes: 82542 x1, 82542 x1, 82570 x1, 82570 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 2-6 days.

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Collection Instructions

Specimen:Urine, random
Optimal Volume:Submit entire collection; analysis requires 1 mL
Minimum\Peds Volume:2 mL
Container:Plastic leakproof container, sterile
Collection Instructions:Collect a random urine specimen. No preservative preferred.

Processing and Shipping

Specimen Processing:Aliquot 5 mL, 2 mL minimum. Store frozen.
Shipping Instructions:Ship frozen.
Stability:24 hours at room temperature; 7 days refrigerated; 30 days frozen (preferred).
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:RLTE4 (Leukotrienne E4, Random Urine)


Use:An aid to evaluate patients suspected of having systemic mastocytosis using random urine collections. Elevated urinary leukotriene E4 (LTE4) concentrations >104 pg/mg creatinine are consistent with the diagnosis of systemic mast cell disease when combined with clinical signs and symptoms. Pharmacological treatment with 5-lipoxygenase inhibitors or leukotriene receptor antagonists has been shown to decrease production of LTE4.

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