Constitutional or Products of Conception (POC) Chromosomal Microarray (Copy Number/SNP)


Abbrev Code:CGHSNP   
Order Code:LAB6575Order Name:Constitutional or Products of Conception (POC) Chromosomal Microarray (Copy Number/SNP)
Synonyms:Comparative Genomic Hybridization (CGH) with Single Nucleotide Polymorphism (SNP array); Products of Conception (POC), Congenital, Constitutional; Single Nucleotide Polymorphism; CGH with SNP; Microarray with SNP
Methodology:Copy Number and SNP Chromosomal Microarray (CMA). Congenital
CPT Codes: 81229 x1, x1, G0452 x1, 88230 x1, 88233 x1
Turnaround Time:Results are reported within 7-21 days.
Special Instructions:
Test request form requires:
  • Date and time of specimen collection
  • Specimen type
  • Patient information: date of birth, sex and medical record number
  • Ordering physician and contact number
  • Reason for referral
  • Clinical status
  • Information regarding medications or transfusions
  • Previous or pending genetic testing results
A signed informed consent in the patient's medical record is required. The consent should not be sent to the laboratory. The link to the Genetic Testing Consent Form is provided as a convenience for the providers and genetic counselors. See Associated Links.
Associated Links:

Genetic Testing Consent Form



Collection Instructions

Specimen:Whole blood; Skin Biopsy, Products of Conception (POC)
Alternative: Cord blood
Whole blood: Both a green (sodium heparin, no gel) tube AND a purple (EDTA) or yellow (ACS) tube must be collected.
Optimal Volume:
  • Whole blood: 5 mL in green (sodium heparin, no gel) AND 5 mL purple (EDTA) or yellow (ACD). Both tubes required for testing.
  • Products of Conception (POC)/Skin: Portion of placenta at least 1 cm3 containing 35-55 mg of Villi.
  • Skin, cord or fetal tissue: 3-4 mm punch skin biopsy If obtained at autopsy, at least 1 cm3 including dermis.
Minimum\Peds Volume:
  • Whole blood: 3 mL in green (sodium heparin, no gel) AND 3 mL purple (EDTA) or yellow (ACD). Both tubes required for testing. 1-3 mL for each tube is acceptable for patients with blood draw limitations. No heelsticks or fingersticks accepted.
  • Products of Conception (POC): 5-10 mg chorionic villi
Container:Plastic leakproof container, sterile, Green (sodium heparin, no gel) AND Purple (EDTA)
Alternate Containers: Yellow (ACD, Solution A) tube available from laboratory
Collection Instructions:
  • Whole blood: Collect BOTH 3-5 mL in green (sodium heparin, no gel) tube AND 3-5 mL in purple (EDTA) or yellow (ACD) tube. The yellow (ACD) is an alternate tube to the EDTA tube only.
  • Products of Conception (POC)/Skin: Collect in plastic leakproof sterile container containing RPMI media. Sterile saline may be used if RPMI is not available.
   
Causes for Rejection:Clotted or frozen sample. Incorrect specimen collection tube (anticoagulant).


Processing and Shipping

Specimen Processing:Do not process. Store at room temperature. Do not refrigerate or freeze.
Specimens must be received in the Cytogenetics Laboratory Mon-Fri by 5:30 pm; weekends and holidays by 4:30 pm. Specimens received after these cutoffs will be processed the following day.
Shipping Instructions:Ship at room temperature.
Stability:For optimal testing results the specimen must arrive within 24 hours of collection.
Test Performed at or Referral Lab Cytogenetics  (UMMC East Bank)


Interpretive

Reference Range:By report.


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