aHUS (complement-mediated TMA) Panel

Abbrev Code:XMISC   
Order Code:LAB4909Order Name:Laboratory Miscellaneous Order
Synonyms:TMA Functional Panel
Methodology:Varies by test
CPT Codes: 83516 x2, 83520 x1, 86160 x11, 86161 x2, 86162 x1, 86334 x1
Test Includes:CH50, APFA, C3b Deposition Assay, FHAA, FBAA, Fluid Phase Activity (IFE), C3, C3c, C4, FD, FB, Ba, Bb, C5, Properdin, Soluble C5b-9, FI and FH levels
Turnaround Time:Specimens are sent to reference laboratory Mon-Thur; results are reported within 4 weeks.
Special Instructions:Diagnostic and clinical information are required for testing. Send a copy of the MORL Kidney Testing Requisition form with each sample.
Associated Links:

MORL Kidney Testing Requisition

Collection Instructions

Optimal Volume:12 mL
Minimum\Peds Volume:8.4 mL
Container:Purple (EDTA), Red (no gel)
Collection Instructions:Testing requires 2 samples: Red (no gel) AND purple (EDTA). Collect 8.4-12 mL, 4.2 mL minimum, each in red (no gel) and purple (EDTA) tubes.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot 2 mL minimum of each EDTA plasma and serum. Clearly indicate sample type on each aliquot tube, Store frozen.
Shipping Instructions:Ship frozen.
Test Performed at or Referral Lab Lab Sendouts  (University Iowa Molecular Otolaryngology & Renal Research Laboratories)
Referral Lab number:aHUS-FP


Reference Range:By report.
Use:TMA Panel testing is recommended for patients with TMAs include HUS, aHUS, and TTP. This testing is also appropriate for patients with other complement-mediated renal diseases such as C3 Glomerulonephritis and Membranoproliferative Glomerulonephritis as 6 of the genes on the panel and MLPA testing have been associated with these diseases.

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