TMA Functional Panel

Abbrev Code:XMISC   
Order Code:LAB4909Order Name:Send Out Misc Test
Methodology:Varies by test
CPT Codes: 83516 x1, 83520 x1, 85397 x1, 86160 x5, 86161 x2, 86162 x1
Test Includes:[Serologies for TTP, aHUS, HUS] CH50, APFA, C3b Deposition Assay, FHAA, C3, C4, FB, Bb, Soluble C5b-9 (sMAC), Fl and FH levels
Turnaround Time:Specimens are sent to reference laboratory Mon-Thur; results are reported within 4 weeks.
Special Instructions:Diagnostic and clinical information are required for testing. Send a copy of the MORL Kidney Testing Requisition form with each sample.
Associated Links:

MORL Kidney Testing Requisition

Collection Instructions

Optimal Volume:12 mL
Minimum\Peds Volume:8.4 mL
Container:Purple (EDTA), Red (no gel)
Collection Instructions:Testing requires 2 samples: Red (no gel) AND purple (EDTA). Collect 8.4-12 mL, 4.2 mL minimum, each in red (no gel) and purple (EDTA) tubes.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot 2 mL minimum of each EDTA plasma and serum. Clearly indicate sample type on each aliquot tube, Store frozen.
Shipping Instructions:Ship frozen.
Test Performed at or Referral Lab Lab Sendouts  (University Iowa Molecular Otolaryngology & Renal Research Laboratories)
Referral Lab number:08TMAFP


Reference Range:By report.
Use:TMA Panel testing is recommended for patients with TMAs include HUS, aHUS, and TTP. This testing is also appropriate for patients with other complement-mediated renal diseases such as C3 Glomerulonephritis and Membranoproliferative Glomerulonephritis as 6 of the genes on the panel and MLPA testing have been associated with these diseases.

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