aHUS (complement-mediated TMA) Panel
| Abbrev Code: | XMISC | ||
| Order Code: | LAB4909 | Order Name: | Laboratory Miscellaneous Order |
| Synonyms: | TMA Functional Panel | ||
| Methodology: | Varies by test | ||
| CPT Codes: | 83516 x2, 83520 x1, 86160 x11, 86161 x2, 86162 x1, 86334 x1 | ||
| Test Includes: | CH50, APFA, C3b Deposition Assay, FHAA, FBAA, Fluid Phase Activity (IFE), C3, C3c, C4, FD, FB, Ba, Bb, C5, Properdin, Soluble C5b-9, FI and FH levels | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Thur; results are reported within 4 weeks. | ||
| Special Instructions: | Diagnostic and clinical information are required for testing. Send a copy of the MORL Kidney Testing Requisition form with each sample. | ||
| Associated Links: | |||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 12 mL |
| Minimum\Peds Volume: | 8.4 mL |
| Container: | Purple (EDTA), Red (no gel) |
| Collection Instructions: | Testing requires 2 samples: Red (no gel) AND purple (EDTA). Collect 8.4-12 mL, 4.2 mL minimum, each in red (no gel) and purple (EDTA) tubes. |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 2 mL minimum of each EDTA plasma and serum. Clearly indicate sample type on each aliquot tube, Store frozen. |
| Shipping Instructions: | Ship frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (University Iowa Molecular Otolaryngology & Renal Research Laboratories) |
| Referral Lab number: | aHUS-FP |
Interpretive
| Reference Range: | By report. |
| Use: | TMA Panel testing is recommended for patients with TMAs include HUS, aHUS, and TTP. This testing is also appropriate for patients with other complement-mediated renal diseases such as C3 Glomerulonephritis and Membranoproliferative Glomerulonephritis as 6 of the genes on the panel and MLPA testing have been associated with these diseases. |
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