Constitutional Chromosomal Microarray (Copy Number/SNP) with Limited G-band Analysis


Abbrev Code:CGSNPL   
Order Code:LAB6601Order Name:Constitutional Chromosomal Microarray (Copy Number/SNP) with Limited G-band Analysis
Synonyms:CGH SNP LHR; Comparative Genomic Hybridization (CGH) with Sigle Nucleotide Polymorphism (SNP Array) with Limited G-bands; CMA (Chromosomal Microarray), Congenital, Constitutional; CGH with SNP with G-Band; Microarray with SNP
Methodology:Chromosomal microarray (CMA) with limited chromosome analysis by G-banding
CPT Codes: 81229 x1, x1, G0452 x1, 88261 x1, 88230 x1, 88233 x1
Turnaround Time:Results are reported within 7-21 days.
Special Instructions:Test request form requires:
  • Date and time of specimen collection
  • Specimen type
  • Patient information: date of birth, sex and medical record number
  • Ordering physician and contact number
  • Reason for referral
  • Clinical status
  • Information regarding medications or transfusions
  • Previous or pending genetic testing results

A signed informed consent in the patient's medical record is required. The consent should not be sent to the laboratory. The link to the Genetic Testing Consent Form is provided as a convenience for the providers and genetic counselors. See Associated Links.
Associated Links:

Genetic Testing Consent Form


Collection Instructions

Specimen:Whole blood; Skin Biopsy, Products of Conception (POC)
Alternative: Cord blood
Whole blood: Both a green (sodium heparin, no gel) tube AND a purple (EDTA) or yellow (ACD) tube must be collected. (Yellow tube is an alternate to the EDTA only.)
Optimal Volume:
  • Whole blood: 5 mL in green (sodium heparin, no gel) AND 5 mL purple (EDTA) or yellow (ACD) tube. Both tubes required for testing.
  • Products of conception (POC)/Skin: Portion of placenta at least 1 cm3 containing 35-55 mg of Villi
  • Skin cord or fetal tissue: 3-4 mm punch skin biopsy. If obtained at autoposy, at least 1 cm3 including dermis.
Minimum\Peds Volume:
  • Whole blood: 3 mL in green (sodium heparin, no gel) AND 3 mL purple (EDTA) or yellow (ACD) tube. Both tubes required for testing. 1-3 mL for each tube will be accepted for patients with blood draw limitations.
  • Products of conception (POC): 5-10 mg chorionic villi
Container:Plastic leakproof container, sterile, Green (sodium heparin, no gel) AND Purple (EDTA)
Alternate Containers: Yellow (ACD, Solution A) tube available from laboratory
Collection Instructions:
  • Whole blood: Collect BOTH 3-5 mL in sodium heparin (green) AND 3-5 mL in purple (EDTA) or yellow (ACD). The yellow ACD is an alternate to the EDTA tube only.
  • Products of Conception (POC)/Skin: Collect in plastic leakproof sterile container containing RPMI media. Sterile saline may be used if RPMI is not available.
Causes for Rejection:Clotted or frozen sample. Incorrect specimen collection tube (anticoagulant).


Processing and Shipping

Specimen Processing:Do not process. Store at room temperature. Do not refrigerate or freeze.
Specimens must be received in the Cytogenetics Laboratory Mon-Fri by 5:30 pm; weekends or holidays by 4:30 pm. Specimens received after these cutoffs will be processed the following day.
Shipping Instructions:Ship at room temperature.
Stability:For optimal testing results the specimen must arrive within 24 hours of collection.
Test Performed at or Referral Lab Cytogenetics  (UMMC East Bank)


Interpretive

Reference Range:By report.


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