Voltage-Gated Potassium Channel (VGKC) Antibody
| Abbrev Code: | VGKCAB | ||
| Order Code: | LAB6678 | Order Name: | Voltage-gated Potassium Channel Antibody |
| Methodology: | Radioimmunoassay | ||
| CPT Codes: | 83519 x1 | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat. Tests are performed on Tues; results are reported within 1-8 days. | ||
| Compliance: | For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes. |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 8 mL |
| Minimum\Peds Volume: | 1.2 mL |
| Container: | Red (no gel) Alternate Containers: Red or gold (gel) |
| Causes for Rejection: | Plasma. Grossly lipemic or icteric specimens. |
Processing and Shipping
| Specimen Processing: | Separate serum from cells within 1 hour of collection. Centrifuge and aliquot 4 mL, 0.5 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | After separation from cells: 72 hours at room temperature; 2 weeks refrigerated; 1 month frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 2004890 |
Interpretive
| Reference Range: |
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| Use: | Voltage-Gated Potassium Channel (VGKC) antibodies are associated with neuromuscular weakness as found in neuromyotomia (also know as Isaacs Syndrome) and Morvan Syndrome. VGKC antibodies are also associated with paraneoplastic neurological syndromes and limbic encephalitis; however, VGKC antibody-associated limbic encephalitis may be associated with antibodies to leucine-rich, glioma-inactivated 1 protein (Lgi1) or contactin-associated protein-2 (Caspr-2) instead of potassium channel antigens. |
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