Angiotensin Converting Enzyme, Serum

Abbrev Code:A1CE   
Order Code:LAB179Order Name:Angiotensin Converting Enzyme
Synonyms:ACE; Gaucher's Disease
CPT Codes: 82164 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-2 days.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Collected in EDTA or heparin plasma; hemolyzed specimens.
Contraindications:Recently administered radioisotopes will interfere with this test, causing spurious results.

Processing and Shipping

Specimen Processing:Separate serum from cells within 2 hours of collection. Centrifuge and aliquot 1 mL, 0.5 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:1 week at room temperature or refrigerated; 6 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80001


Reference Range:
Age U/L
0-6 y 18-90
7-14 y 24-121
15-17 y 18-101
18 y and older 16-85
Use:Significant increases in serum ACE are observed in 75% of patients with active pulmonary sarcoidosis. Rarely, ACE in serum is increased in patients suffering from other types of lung disease such as pulmonary tuberculosis, coccidioidomycosis, lung cancer, or from other types of granulomatous disease. ACE activity is a helpful test for the differential diagnosis of sarcoidosis. Increased ACE activity has also been reported in Gaucher's disease, leprosy, silicosis, asbestosis, and in 24% of patients with diabetes mellitus. The enzyme also seems to play a key physiological role in the regulation of blood pressure. In patients with active sarcoidosis, enzyme values fall within the reference interval during spontaneous remission or after appropriate corticosteroid treatment. Therefore, the assay is useful in following the clinical course of the disease and therapy effectiveness.

Click HERE to Report test errors or omissions.
*If no email program is associated with this computer, please contact: for TestID: 653"