5-a-Dihydrotestosterone


Abbrev Code:DHTEST   
Order Code:LAB977Order Name:Dihydrotestosterone
Synonyms:DHT; Dihydrotestosterone Sulfate
Methodology:High performance liquid chromatography/Tandem mass spectrometry
CPT Codes: 82642 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.
Compliance:

For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.4 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Hemolyzed or lipemic specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.6 mL minimum within 2 hours of collection. Freeze immediately.
Shipping Instructions:Ship on dry ice.
Stability:Stability: After separation from cells: 48 hours at room temperature; 5 days refrigerated; 6 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2002349


Interpretive

Reference Range:
Female pg/mL
Premature 20.0-130
0-6 d, Full term 20.0-150.00
1 w - 9 y 0-49.9
10-19 y 50.0-170.0
20 y and older 24.0-208.0
 
Tanner Stage I: 1.0-64.3
Tanner Stage II: 5.5-95.9 pg/mL
Tanner Stage III: 11.4-158.3 pg/mL
Tanner Stage IV & V: 18.7-193.8 pg/mL
 
Male pg/mL
Premature 100-530
0-6 d, Full term 50.0-600.0
1 w - 6 mo 120.0-850.0
7 mo - 9 y 0-49.9
10-19 y 0-533.0
20 y and older 106.0-719.0

Tanner Stage I: 1.0-47.6 pg/mL
Tanner Stage II: 3.5-397.9 pg/mL
Tanner Stage III: 14.8-574.6 pg/mL
Tanner Stage IV & V: 44.9-511.8 pg/mL
Use:

Dihydrotestosterone (DHT) is the primary androgenic hormone and is formed by the peripheral action of 5-a-reductase on testosterone. Individuals with a deficiency of 5-a-reductase fail to develop male genitalia and appear to be phenotypic females. DHT and its metabolites are reduced in these patients. Finasteride (ProscarÒ) inhibits 5-a-reductase activity and reduces serum DHT concentrations.

 

 



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