5-a-Dihydrotestosterone
| Sunquest Code: | DHTEST | ||
| Epic Code: | LAB977 | Epic Name: | Dihydrotestosterone |
| Synonyms: | DHT; Dihydrotestosterone Sulfate | ||
| Methodology: | High performance liquid chromatography/Tandem mass spectrometry | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days. | ||
| Compliance: | This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes. |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2 mL |
| Minimum\Peds Volume: | 1.4 mL |
| Container: | Red or gold (gel) (Red (no gel)) |
| Causes for Rejection: | Hemolyzed or lipemic specimens. |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 1 mL, 0.6 mL minimum within 2 hours of collection. Freeze immediately. |
| Shipping Instructions: | Ship on dry ice. |
| Stability: | Stability: After separation from cells: 48 hours at room temperature; 5 days refrigerated; 6 months frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 2002349 |
Interpretive
| Reference Range: |
Tanner Stage I: 1.0-64.3 Tanner Stage II: 5.5-95.9 pg/mL Tanner Stage III: 11.4-158.3 pg/mL Tanner Stage IV & V: 18.7-193.8 pg/mL
Tanner Stage I: 1.0-47.6 pg/mL Tanner Stage II: 3.5-397.9 pg/mL Tanner Stage III: 14.8-574.6 pg/mL Tanner Stage IV & V: 44.9-511.8 pg/mL |
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| Use: |
Dihydrotestosterone (DHT) is the primary androgenic hormone and is formed by the peripheral action of 5-a-reductase on testosterone. Individuals with a deficiency of 5-a-reductase fail to develop male genitalia and appear to be phenotypic females. DHT and its metabolites are reduced in these patients. Finasteride (ProscarÒ) inhibits 5-a-reductase activity and reduces serum DHT concentrations.
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