JAK2 Single Gene by NGS
Abbrev Code: | JAK2SG | ||
Order Code: | LAB8045 | Order Name: | Jak2 Mutation NGS Analysis |
Synonyms: | V617F; Exon 12 | ||
Methodology: | Next generation sequencing | ||
CPT Codes: | G0452 x1, 81270 x1, 81403 x1 | ||
Turnaround Time: | Performed Mon-Fri; results are reported within 10-14 days. |
Collection Instructions
Specimen: | Blood or bone marrow |
Optimal Volume: | 10 mL blood; 3 mL bone marrow |
Minimum\Peds Volume: | 3 mL blood; 1 mL bone marrow |
Container: | Yellow (ACD, Solution A) tube available from laboratory Alternate Containers: Purple (EDTA) |
Collection Instructions: | Bone marrow clot acceptable for testing. |
Causes for Rejection: | Frozen or clotted specimen, incorrect anticoagulant, specimen more than 5 days old.
Shared blood and bone marrow samples will not be accepted unless sent to Molecular Diagnostics first. Contamination will occur on automated hematology analyzers. |
Processing and Shipping
Specimen Processing: | Do not process. Store at room temperature. |
Shipping Instructions: | Ship at room temperature. Do not refrigerate or freeze. |
Stability: | Whole blood samples are stable for 5 days at room temperature. do not refrigerate or freeze. |
Test Performed at or Referral Lab | Molecular Diagnostics (UMMC East Bank) |
Interpretive
Reference Range: | See interpretive report. |
Use: | This test is indicated in the diagnostic workup of a person suspicious for myeloproliferative neoplasm (MPN) and for monitoring disease status. The 2017 WHO diagnostic criteria includes molecular testing for JAK2 V617F or JAK2 exon 12 mutations for PV. A positive JAK2 V617F mutation with other supporting clinical signs means it is likely that the person has an MPN. More than 90% of polycythemia vera (PV) patients and 60% of patients with essential thrombocythemia (ET) or primary myelofibrosis (MF) have a JAK2 V617F mutation. |
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