Aldosterone/Renin Activity Ratio Panel


Abbrev Code:ALDRR   
Order Code:LAB8130Order Name:Aldosterone/Renin Activity Ratio
Order Instructions:Order Aldosterone (ALDO), Renin Activity (RENIN), and Aldosterone/Renin Activity Ratio (ALDRR) on the same number.
Synonyms:RENIN; ALDO
Methodology:Chemiluminescent immunoassay/Enzyme linked immunosorbent assay
CPT Codes: 82088 x1, 84244 x1, x1
Test Includes:Renin Activity (RENIN) sent to ARUP, and Aldosterone Level (ALDO) and Aldosterone/Renin Ratio (ALDRR) are performed in Specialty Core.
Turnaround Time:
  • Renin Activity (RENIN) samples are sent to the reference laboratory Mon-Sat; results are reported within 1-5 days.
  • Aldosterone (ALDO) samples are performed Tuesdays and Fridays; results are reported the same day.
  • Aldosterone/Renin Activity Ratio (ALDRR) will be reported once the Renin Activity and Aldosterone samples are complete.
Special Instructions:Send both serum and plasma (EDTA).


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL in red or gold (gel) or red (no gel) and 4 mL purple (EDTA)
Minimum\Peds Volume:1.2 mL in red or gold (gel) or red (no gel) and 2.6 mL purple (EDTA).
Container:Purple (EDTA), Red or gold (gel)
Alternate Containers: Red (no gel) & purple (EDTA)
Collection Instructions:Collect both serum and plasma (EDTA). Do not collect in refrigerated tubes.
Patient Preparation:Collect mid-morning after patient has been sitting, standing or walking for at least 2 hours, and seated for 5-15 minutes.
Causes for Rejection:Plasma collected in citrate, heparin or oxalate. Hemolyzed specimens.


Processing and Shipping

Specimen Processing:Within 2 hours of collection, centrifuge and aliquot 1 mL; 0.5 mL minimum serum and 2 mL; 1.2 mL minimum plasma. Store and ship at frozen temperature. Plasma is critical frozen and separate specimens must be submitted when additional tests are ordered.
Shipping Instructions:Ship at frozen temperature.
Stability:Serum: 8 hours at room temperature; 5 days refrigerated; 1 month frozen.
Plasma: 6 hours at room temperature; refrigerated is unacceptable; 1 month frozen.
Test Performed at or Referral Lab Specialty Core (UMMC East) and Sendout (ARUP)  (ARUP)
Referral Lab number:70105 (Renin)


Interpretive

Reference Range:
Aldosterone, Serum  
Age Posture Unspecified
0-6 d 5.0-102.0 ng/dL
1-3 w 6.0-179.0 ng/dL
1-11 mo 7.0-99.0 ng/dL
1-2 y 7.0-93.0 ng/dL
3-10 y 4.0-44.0 ng/dL
11-14 y 4.0-31.0 ng/dL
15 y & older ≤ 31.0 ng/dL
 
 
Renin Activity    
Adult, normal
sodium diet		 Children, normal
sodium diet, supine		 Children, normal
sodium diet, upright
Supine: 0.2-1.6
ng/mL/hr		 Newborn (1-7 d):
2.0-35.0 ng/mL/hr		 0-3 y: not available
Upright: 0.5-4.0
ng/mL/hr		 Cord Blood:
4.0-32.0 ng/mL/hr		 4-5 y:
≤ 15 ng/mL/hr
  1-12 mo:
2.4-37.0 ng/mL/hr		 6-10 y:
≤ 17 ng/mL/hr
  13 mo-3 y:
1.7-11.2 ng/mL/hr		 11-15 y:
≤ 16 ng/mL/hr
  4-5 y:
1.0-6.5 ng/mL/hr		  
  6-10 y:
0.5-5.9 ng/mL/hr		  
  11-15 y:
0.5-3.3 ng/mL/hr		  
 
Aldosterone/Renin Activity Calculation: Less than 25.
Use:Screen and diagnose hyperaldosteronism.


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