Acute Myeloid Leukemia (AML) Molecular Follow-Up, Blood or Bone Marrow Panel

Abbrev Code:AMLFUB   
Order Code:LAB8047Order Name:AML Molecular Follow Up NGS Blood BM
Order Instructions:Not appropriate for a new AML patient. Order either the Acute Myeloid Leukemia Focused NGS Panel (AMLFCB) or Acute Myeloid Leukemia Expanded Panel (AMLEXB)
Synonyms:FLT3; NPM1; CEBPA; IDH1; IDH2
Methodology:Next generation sequencing
CPT Codes: G0452 x
Test Includes:Follow-up testing for AML will be performed for all the gene(s) positive in the diagnostic sample. In addition, FLT3, IDH1 and IDH2 will be performed for relapsed AML specimens. FLT3 (ITD, TKD) testing will be reported additionally as a separate report within 3-5 days
All testing will be canceled if engraftment testing is 100% donor engrafted in consultation with clinician.
Turnaround Time:Performed Mon-Fri; results are reported within 10-14 days.
Special Instructions:A signed informed consent in the patient's medical record is required; the consent should not be sent to the laboratory. The link to the Genetic Testing Consent Form is provided as a convenience for the providers and genetic counselors.

Bone Marrow Transplant Patients: If a patient is the recipient of an allogeneic transplant, this test must be done on a pre-transplant sample. Contact the Molecular Diagnostics lab to see if a pre-transplant sample is available.
Associated Links:

NGS Genetic Testing Consent Form, Gene Specific CPT Codes for Genetic Sequencing

Collection Instructions

Specimen:Blood, bone marrow
Optimal Volume:10 mL blood; 3 mL bone marrow
Minimum\Peds Volume:3 mL blood; 1 mL bone marrow
Container:Yellow (ACD, Solution A) tube available from laboratory
Alternate Containers: Purple (EDTA)
Collection Instructions:Bone marrow clot acceptable for testing
Causes for Rejection:Whole blood: frozen or clotted specimen, incorrect anticoagulant, specimen more than 5 days old. All testing will be cancelled if engraftment testing is 100% donor engrafted in consultation with clinician.
Shared blood or bone marrow samples will not be accepted unless sent to Molecular first. Contamination will occur on automated hematology analyzers.
Follow-up samples for the hematology panels will be tested for all gene(s) positive in the diagnostic sample and FLT3.

Processing and Shipping

Specimen Processing:Do not process. Store at room temperature.
Shipping Instructions:Ship at room temperature. Do not refrigerate or freeze.
Stability:Whole blood samples are stable for 5 days at room temperature. Do not refrigerate or freeze.
Test Performed at or Referral Lab Molecular Diagnostics  (UMMC East Bank)


Reference Range:See interpretive report.
Use:Follow-up testing for AML.

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