Phosphatidylethanol (PEth), Whole Blood


Abbrev Code:PETH   
Order Code:LAB1143Order Name:Phosphatidylethanol (PEth), Whole Blood
Synonyms:1, 2-dioleoyl-sn-glycero-3 phosphoethanol; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol
Methodology:Quantitative liquid chromatography/Tandem mass spectrometry
CPT Codes: 80321 x1, 80321` x1
Turnaround Time:Specimens are sent to the reference laboratory Sun-Sat; results are reported within 1-4 days.
Compliance:

This test uses a manufacturer labeled Analyte Specific Reagent (ASR) as the reagent providing the specificity of the assay. The test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.



Collection Instructions

Specimen:Whole blood
Optimal Volume:1 mL
Minimum\Peds Volume:0.5 mL
Container:Purple (EDTA)
Alternate Containers: Green (lithium heparin, no gel), Gray (sodium fluoride + potassium oxalate)
Causes for Rejection:Gel separator tubes, plain red, light blue (citrate) or yellow (SPS or ACD solution).


Processing and Shipping

Specimen Processing:Whole blood, do not process. Store in refrigerator.
Shipping Instructions:Ship refrigerated; frozen is also acceptable.
Stability:2 hours at room temperature; 2 weeks refrigerated; 1 month (-20°C) frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3002598


Interpretive

Reference Range:By report.
Use:Biomarker associated with ethanol consumption; may be helpful in monitoring alcohol abstinence.

Phosphatidylethanol (PEth) is a group of phospholipids formed in the presence of ethanol, phospholipase D and phosphatidylcholine. PEth is known to be a direct alcohol biomarker. The predominant PEth homologues are PEth 16:0/18:1 (POPEth) and PEth 16:0/18:2 (PLPEth), which accounts for 37-46% and 26-28% of the total PEth homoogues, respectively. PEth is incorporated into the phospholipid membrane of red blood cells and has a general half-life of 4-10 days and a window of detection of 2-4 weeks. However, the window of detection is longer in individuals who chronically or excessively consume alcohol. Serial monitoring of PEth may be helpful in monitoring alcohol abstinence over time. PEth results should be interpreted in the context of the patient's clinical and behavioral history. Patients with advanced liver disease may have falsely elevated PEth concentrations (Ngyuen VL et al 2018, Alcoholism Clinical & Experimental Research).


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