Scleroderma (Scl-70) (ENA) Antibody, IgG


Abbrev Code:SCLIGG   
Order Code:LAB6367Order Name:Scleroderma AB (Scl-70) (ENA) IgG
Synonyms:SCL-70; Antitopoisomerase-1; Anti-Scleroderma Antibody
Methodology:Fluorescent enzyme immunoassay
CPT Codes: 86235 x1
Turnaround Time:Performed twice weekly; results are reported within 4 days.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.9 mL
Container:Red or gold (gel)
Alternate Containers: Green (lithium heparin, gel), Purple (EDTA), Red (no gel)
Causes for Rejection:Gross hemolysis


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.35 mL minimum. Store in refrigerator up to 14 days.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Endocrine  (UMMC-East Bank)


Interpretive

Reference Range:
Negative Less than 7.0 U/mL
Positive Greater than 10 U/mL
Use:Scleroderma (Scl-70) antibody is seen in 20-60% of patients with scleroderma and is considered diagnostic and specific for scleroderma if it is the only ENA antibody present. Scl-70 is also seen in approximately 25% of progressive systemic sclerosis (PSS).


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