Encephalopathy, Autoimmune Evaluation, Serum, Adult

Abbrev Code:ENS2   
Order Code:LAB812Order Name:Encephalopathy, Autoimmune Evaluation, Serum, Adult
Order Instructions:For patients 18 years and older. For pediatric testing, order Mayo's PCDES via LAB4909.
Methodology:Indirect Immunofluorescence Assay (IFA), Cell-Binding Assay (CBA), Western Blot (WB), Immunoblot (IB), Radioimmunoassay (RIA)
CPT Codes: 86255 x21, 86255 x21, 86341 x1, 86341 x1, 86256 x19, 84182 x7, 86255 x9
Test Includes:See Encephalopathy Autoimmune Evaluation Algorithm-Serum Associated Link.
Turnaround Time:Specimens are sent to the reference laboratory Mon-Fri; results are reported within 11-14 days.

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Associated Links:

Autoimmune/Paraneoplastic Encephalopathy Evaluation Algorithm-Serum, Central Nervous System Demyelinating Disease Diagnostic Algorithm

Collection Instructions

Optimal Volume:8 mL
Minimum\Peds Volume:5.2 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Patient Preparation:
  1. For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
  2. This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed, or canceled if radioactivity remains.
  3. Patient should have no general anesthetic or muscle-relaxant drugs in the previous 24 hours.
Causes for Rejection:Grossly lipemic, hemolyzed or icteric.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot 4 mL, 2.5 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:72 hours at room temperature; 28 days refrigerated (preferred) or frozen.
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:ENS2


Reference Range:By report.
Use:Evaluating new onset encephalopathy.

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