Pharmacogenomics Profile


Abbrev Code:PGX   
Order Code:LAB8161Order Name:Pharmacogenomics Profile
Methodology:SNP Genotyping of selected drug-metabolizing enzymes using Fluidigm BioMark HD and Life Technologies TaqMan®
CPT Codes: G0452 x1, 81225 x1, 81227 x1, 81226 x1, 81231 x1, 81232 x1, 81328 x1, 81350 x1, 81335 x1
Test Includes:The assay tests for the following genes and star alleles: CYP2B6*9, CYP2C19*2, CYP2C19*3, CYP2C19*4, CYP2C19*5, CYP2C19*6, CYP2C19*8, CYP2C19*17, CYP2C9*2, CYP2C9*3, CYP2C9*5, CYP2C9*6, CYP2C9*8, CYP2C9*11, CYP2D6*2 (*34), CYP2D6*2 (*39), CYP2D6*3, CYP2D6*4, CYP2D6*6, CYP2D6*10, CYP2D6*17, CYP2D6*41, CYP3A5*3, DPYD D949V, DPYD*2A, DPYD*13, SLCO1B1*5, TPMT*2, TPMT*3B, TPMT*3C, TPMT*4, UGT1A1*80 as well as provides the information of the CYP2D6 copy number.  The Go4PGx PDF based report includes additional diplotype-phenotype information as well as gene-phenotype-drug recommendations based on CPIC guidelines.
Turnaround Time:Testing is performed Mon-Fri; results are reported within 7-10 days.
Special Instructions:A signed informed consent in the patient's medical record is required. The consent should not be sent to the laboratory. The link to the Genetic Testing Consent Form is provided as a convenience for the providers and genetic counselors within the order.
Associated Links:

Genetic Testing Consent Form



Collection Instructions

Specimen:Blood (ACD or EDTA) and Buccal swab of cheek.
Optimal Volume:Blood ACD or EDTA: 10 mL
Two Genotek OraCollect-DX (OCD-100) buccal swabs
Minimum\Peds Volume:Blood ACD or EDTA: 3 mL
One OraCollect buccal swab
Container:Yellow (ACD, Solution A) tube available from laboratory
Alternate Containers: Purple (EDTA), Yellow (ACD, Solution B) tube available from laboratory
Causes for Rejection:Blood samples tested in hematology using automated instrumentation not accepted. DNA extracted at a non-CLIA certified (or equivalent) lab.


Processing and Shipping

Specimen Processing:Do not process. Store at room temperature.
Shipping Instructions:Ship at room temperature.
Stability:5 days at room temperature.
Test Performed at or Referral Lab UM Molecular Diagnostics (M)  (UMMC East Bank)


Interpretive

Reference Range:By report.
Use:Pharmacogenomic (PGx) testing is performed at the MHealth Fairview Molecular Diagnostic Laboratory. It uses targeted genotyping technology to evaluate the presence of DNA variants tht affect the metabolism of certain medications, Whole blood and buccal swab samples are acceptable DNA sources for PGx testing.


Click HERE to Report test errors or omissions.
*If no email program is associated with this computer, please contact:
systemlabguide@fairview.org for TestID: 6787"