Pharmacogenomics Profile
| Abbrev Code: | PGX | ||
| Order Code: | LAB8161 | Order Name: | Pharmacogenomics Profile |
| Synonyms: | Pharmacogenetics | ||
| Methodology: | SNP Genotyping of selected drug-metabolizing enzymes using Fluidigm BioMark HD and Life Technologies TaqMan® | ||
| CPT Codes: | G0452 x1, 81418 x1, 81418 x1 | ||
| Test Includes: | The assay tests for the following genes and star alleles: CYP2B6*9, CYP2C19*2, CYP2C19*3, CYP2C19*4, CYP2C19*5, CYP2C19*6, CYP2C19*8, CYP2C19*17, CYP2C9*2, CYP2C9*3, CYP2C9*5, CYP2C9*6, CYP2C9*8, CYP2C9*11, CYP2D6*2 (*34), CYP2D6*2 (*39), CYP2D6*3, CYP2D6*4, CYP2D6*6, CYP2D6*10, CYP2D6*17, CYP2D6*41, CYP3A5*3, DPYD D949V, DPYD*2A, DPYD*13, SLCO1B1*5, TPMT*2, TPMT*3B, TPMT*3C, TPMT*4, UGT1A1*80 as well as provides the information of the CYP2D6 copy number. The Go4PGx PDF based report includes additional diplotype-phenotype information as well as gene-phenotype-drug recommendations based on CPIC guidelines. | ||
| Turnaround Time: | Testing is performed Mon-Fri; results are reported within 7-10 days. | ||
| Special Instructions: | A signed informed consent in the patient's medical record is required. The consent should not be sent to the laboratory. The link to the Genetic Testing Consent Form is provided as a convenience for the providers and genetic counselors within the order. | ||
| Associated Links: | |||
Collection Instructions
| Specimen: | Blood (ACD or EDTA) or Buccal swab of cheek. |
| Optimal Volume: | Blood ACD or EDTA: 10 mL
OR Two Genotek OraCollect-DX (OCD-100) buccal swabs |
| Minimum\Peds Volume: | Blood ACD or EDTA: 3 mL
OR One OraCollect buccal swab |
| Container: | Yellow (ACD, Solution A) tube available from laboratory Alternate Containers: Purple (EDTA), Yellow (ACD, Solution B) tube available from laboratory |
| Causes for Rejection: | Blood samples tested in hematology using automated instrumentation not accepted. DNA extracted at a non-CLIA certified (or equivalent) lab. |
Processing and Shipping
| Specimen Processing: | Do not process. Store at room temperature. |
| Shipping Instructions: | Ship at room temperature. |
| Stability: | 5 days at room temperature. |
| Test Performed at or Referral Lab | UM Molecular Diagnostics (M) (UMMC East Bank) |
Interpretive
| Reference Range: | By report. |
| Use: | Pharmacogenomic (PGx) testing is performed at the MHealth Fairview Molecular Diagnostic Laboratory. It uses targeted genotyping technology to evaluate the presence of DNA variants tht affect the metabolism of certain medications, Whole blood and buccal swab samples are acceptable DNA sources for PGx testing. |
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