TPMT and NUDT15


Abbrev Code:ARMISC   
Order Code:LAB4909Order Name:Send Outs Misc Test
Synonyms:Thiopurine Methyltransferase; Nudix Hydrolase 15
Methodology:Polymerase Chain Reaction/Fluorescence Monitoring
CPT Codes: 81335 x1, 81306 x1
Turnaround Time:Specimens are sent to the reference laboratory Mon-Sat; results are reported within 5-10 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes. Counseling and informed consent are recommended for genetic testing.



Collection Instructions

Specimen:Whole blood
Optimal Volume:3 mL
Minimum\Peds Volume:1 mL
Container:Purple (EDTA)
Alternate Containers: Yellow (ACD, Solution A) tube available from laboratory
Causes for Rejection:Plasma or serum. Specimens collected in sodium heparin or lithium heparin.


Processing and Shipping

Specimen Processing:Do not process. Whole blood. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:72 hours at room temperature; 1 week refrigerated; 1 month frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3001535


Interpretive

Reference Range:By report.
Use:Genotype test to assess risk, due to genetics, for severe myelosuppression with standard dosing of thiopurine drugs. Use for individuals being considered for thiopurine therapy or who have had an adverse reaction to thiopurine therapy.


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