Mycobacterium tuberculosis Infection by QuantifERON-TB Gold Plus
Abbrev Code: | QFT | ||
Order Code: | LAB8219 | Order Name: | Quantiferon TB Gold Plus |
Synonyms: | QTF; Latent TB; Latent tuberculosis; LTBI; Mycobacteria; Quantiferon Gold Plus; Interferon Gamma Release Assay (IGRA); QPLUS | ||
Methodology: | Interferon-y release assay (IGRA) by chemiluminescence immunoassay | ||
CPT Codes: | 86481 x1 | ||
Turnaround Time: | Performed Mon-Fri; results are reported within 2-4 days. |
Collection Instructions
Specimen: | Blood |
Optimal Volume: | 1.0 mL in each of four tubes from QTB Plus collection kit. |
Minimum\Peds Volume: | 0.8 mL in each of four tubes from QTB Plus collection kit. |
Container: | QuantiFERON QTB Gold PLUS Collection Kit (available from lab) |
Collection Instructions: | QFT tubes should be the last tubes collected during a blood draw.
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Causes for Rejection: | Specimens other than those collected and processed according to instructions in the QuantiFERON QTB Gold PLUS Collection Kit. |
Processing and Shipping
Specimen Processing: | Samples are sent to the East Core Laboratory. East Core will process and send test ready sanples to Specialty Core for testing.
Order Instructions:
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Shipping Instructions: | Ship non-incubated samples at room temperature within 12 hours.
Ship incubated samples at refrigerated temperatures in a labeled QTB Plus transport bag. |
Test Performed at or Referral Lab | (Final destination (UMMC East Core) will process and send to testing lab (UMMC Specialty Core) |
Interpretive
Reference Range: | By report. |
Use: | Aids in the diagnosis of Mycobacterium tuberculosis infection, including latent tuberculosis infection (LTBI) and tuberculosis (TB) disease. QFT-G can be used in all circumstances in which the tuberculin skin test is currently used, including contact investigations, evaluation of recent immigrants who have had BCG vaccination and TB screening of health care workers and others, undergoing serial evaluation for M. tuberculosis. However, caution should be used when testing certain populations because of limited data in the use of QFT-G.
New guidelines around TB testing were published on Dec 12, 2016, in Clinical Infectious Disease®2017;64(2):111-5. The new guidelines were the outcome of a task force made up of the American Thoracic Society (ATS), the US Centers for Disease control and Prevention (CDC), and the Infectious Diseases Society of America (IDSA). These three organizations joined forces to broaden the preferential recommendation of modern blood-based TB tests over the 100 year old tuberculin skin test (TST). The task force recommends performing an interfon-g release assay (IGRA) rather than a tuberculin skin test (TST) in individuals >5 years old who meet the following criteria:
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