Myasthenia Gravis (MG) Evaluation with MuSK Reflex


Abbrev Code:MGRM   
Order Code:LAB1072Order Name:Myasthenia Gravis (MG) Evaluation with Musk Reflex
Methodology:Radioimmunoassay (RIA), Flow cytometry
CPT Codes: 83519 x1
Turnaround Time:Specimens are sent to the reference laboratory Mon-Fri; results are reported within 3-11 days.
Compliance:

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.



Collection Instructions

Specimen:Blood
Optimal Volume:6 mL
Minimum\Peds Volume:4.2 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Patient Preparation:
  1. Patient should have no general anesthetic or muscle relaxant drugs in the preceding 24 hours.
  2. For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication.
  3. This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed, or canceled ir radioactivity remains.
Causes for Rejection:Grossly hemolyzed, icteric or lipemic specimens.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 3 mL, 2 mL minimum. Store refrigerated.
Shipping Instructions:Ship refrigerated.
Stability:72 hours at room temperature; 28 days refrigerated (preferred) or frozen.
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)
Referral Lab number:MGMR


Interpretive

Reference Range:Ach Receptor (Receptor Muscle) Binding Ab: ≤ 0.02 nmol/L
AChR Modulating Flow Cytometry, S (if reflexed): Negative
Musk Autoantibody, S (if reflexed): ≤ 0.02 nmol/L
Use:Diagnosis for autoimmune myasthenia gravis (MG) in adults and children.


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