Drug Profile, Targeted by Tandem Mass Spectrometry and Enzyme Immunoassay, Urine


Abbrev Code:PAIN HYB U   
Order Code:LAB1247Order Name:Drug Profile Targeted by TMS/EIA Urine
Methodology:Qualitative liquid chromatography-Tandem mass spectrometry/Enzyme immunoassay/Quantitative-spectrophotometry
CPT Codes: 80364 x1, 80326 x1, 80347 x1, 80355 x1, 80307 x1, 80364 x1, 80326 x1, 80347 x1, 80355 x1, 80307 x1
Test Includes:Refer to information in Reference Range.
Turnaround Time:Specimens are sent to the reference laboratory Sun-Sat; results are reported within 1-3 days.
Compliance:

ARUP Laboratory Developed Test (LDT): For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Associated Links:

Urine Collection Procedure



Collection Instructions

Specimen:Urine, random collection
Optimal Volume:Submit entire collection; analysis requires 8 mL.
Minimum\Peds Volume:4 mL
Container:Plastic leakproof container, sterile
Causes for Rejection:Specimens exposed to repeated freeze/thaw cycles; additives added to urine.


Processing and Shipping

Specimen Processing:Aliquot 4 mL, 2 mL minimum urine into each of two (2) transport tubes with no additives or preservatives.
Shipping Instructions:Ship at refrigerated temperature.
Stability:1 week at room temperature; 1 month refrigerated or frozen.
Clonazepam may be unstable at room temperatures beyond 3 days.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2007479


Interpretive

Reference Range:
Drugs/Drug Classes Cutoff
Concentrations
Barbiturates 200 ng/mL
Benzodiazepine-like:
alprazolam, clonazepam, diazepam, lorazepam,
midazolam, nordiazepam, oxazepam, 
temazepam, zolpidem
20-60 ng/mL
Cannabinoids (11-nor-9-carboxy-THC) 20 ng/mL
Ethyl Glucuronide 500 ng/mL
Muscle Relaxant(s):
carisoprodol, meprobamate
100 ng/mL
Opiates/Opioids:
buprenorphine, codeine, fentanyl, heroin,
hydrocodone, hydromorphone, meperidine,
methadone, morphine, naloxone, oxycodone
oxymorphone, tapentadol, tramadol
2-200 ng/mL
GABA analogues:
gabapentin, pregabalin
100 ng/mL
Phencyclidine (PCP) 25 ng/mL
Stimulants:
amphetamine, cocaine, methamphetamine,
methylphenidate, MDMA (Ecstasy), MEDA (Eve),
MDA, phentermine.
50-200 ng/mL
Note: Some drugs are identified based on the presence of unique drug metabolite not listed above.
The absence of expected drug(s) and/or drug metabolite(s) may indicate noncompliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration must be greater than or equal to the cutoff concentration to be reported as present. If specific drug concentrations are required, contact the laboratory within two weeks of specimen collection to request confirmation and quantification by a second analytical technique. Interpretive questions should be directed to the laboratory.   Results based on immunoassay detection that do not match clinical expectations should be interpreted with caution. Confirmatory testing by mass spectrometry for immunoassay-based results is available, if ordered within two weeks of specimen collection. Additional charges apply.   For medical purposes only; not valid for forensic use.
Use:Urine toxicology test to monitor medication compliances and detect undisclosed drug/substance use to support pain management, substance use disorders treatment, and other pharmacotherapies involving controlled substances. Testing is qualitative and uses a combination of mass spectrometry as well as immunoassays with documented low false positive rates. Secondary testing is generally not indicated but is available if confirmation or quantitation is desired.


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