Allergen: White Hickory, IgE


Abbrev Code:AT15   
Order Code:LAB1063Order Name:Allergen White Hickory, IgE
Synonyms:LHE LAB1715
Methodology:FEIA (by ImmunoCAP)
CPT Codes: 86003 x1, 86003 x1
Turnaround Time:Performed Mon-Fri; results are reported within 4 days.


Collection Instructions

Specimen:Blood
Optimal Volume:1 mL
Minimum\Peds Volume:0.8 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Gross hemolysis or gross lipemia.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 0.5 mL, 0.3 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:14 days refrigerated (preferred); 90 days frozen
Test Performed at or Referral Lab (Mayo)
Referral Lab number:MAYO WHIC


Interpretive

Reference Range:
Class IgE kU/L Interpretation
0 <0.35 Negative
1 0.35-0.69 Equivocal
2 0.70-3.49 Positive
3 3.50-17.4 Positive
4 17.5-49.9 Strongly positive
5 50.0-99.9 Strongly positive
6 ≥100 Strongly positive
Reference values apply to all ages.

Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the concentration fo IgE antibodies expressed as a class score of kU/L.
Limitations:Testing for IgE antibodies is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists, or in patients in whom the medical management does not depend upon identification of allergen specificity.

Some individuals with clinically insignificant sensitivity to allergens may have measurable levels of IgE antibodies in serum, and results must be interpreted in the clinical context.

False positive results of IgE antibodies may occur in patients with markedly elevated serum IgE (>2500 kU/L) due to nonspecific binding to allergen solid phases.
Use:Detection of possible allergic responses to various substances in the environment such as animals, foods, grasses, house dust, mites, insects, insulin, molds, smuts, trees or weeds. Evaluation of hay fever, extrinsic asthma, atopic eczema or respiratory allergy.


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