Western Equine Encephalitis Antibody, IgG and IgM


Abbrev Code:WEEP   
Order Code:LAB1060Order Name:Western Equine Encephalitis Antibody, IgG and IgM
Synonyms:LHE1215; Arbovirus Serology
Methodology:Immunofluorescence assay
CPT Codes: 86654 x2, 86654 x2
Turnaround Time:Performed Mon-Fri (May-Oct) and Mon-Wed-Fri (Nov-Apr); results are reported within 1-4 days.
Special Instructions:Lab Test Record: 1234010601
Compliance:

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.5 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Gross hemolysis or gross lipemia.


Processing and Shipping

Specimen Processing:Within 2 hours of collection, centrifuge and aliquot 1 mL, 0.15 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Room temperature is unacceptable; 14 days refrigerated (preferred); 14 days frozen.
Test Performed at or Referral Lab Lab Sendouts  (Mayo Medical Laboratories)


Interpretive

Reference Range:All ages:
IgG <1.10
IgM <1.10
  Interpretation:
  • IgG antibody is generally detectable within 1-3 weeks of onset, peaking within 1-2 months, and declining slowly thereafter.
  • IgM class antibody is reliably detected within 1-3 weeks of onset, peaking and rapidly declining within 3 months.
  • Single serum specimen IgG ≥1:10 indicates exposure to the virus.
  • Results from a single serum specimen can differentiate early (acute) infection from past infection with immunity if IgM is positive (suggests acute infection).
  • A 4-fold or greater rise in IgG antibody titer in acute and convalescent sera indicate recent infection.
  • In the U.S. it is unusual to react to more than 1 of the arboviral antigens, although Western Equine Encephalitis (WEE) and Eastern Equine Encephalitis (EEE) antigens will show some cross-reactivity; however, antibody response to the infecting virus is typically at least 8-fold higher.
  • Infections with arboviruses can occur at any age. The severity of the host response may be influenced by age; WEE tends to produce the most severe clinical infections in young persons. Infection in males is primarily due to work and sports activity.
Use:Aids in the diagnosis of Western Equine Encephalitis.


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