Gentamicin
| Abbrev Code: | GENT | ||
| Order Code: | LAB28 | Order Name: | Gentamicin Level |
| Methodology: | CEDIA homogenous enzyme immunoassay | ||
| CPT Codes: | 80170 x1, 80170 x1 | ||
| Turnaround Time: | Performed and reported 24 hours/day. | ||
| Special Instructions: | Comment last dose information on request. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.5 mL |
| Minimum\Peds Volume: | 0.6 mL |
| Container: | Red (no gel) |
| Collection Instructions: | Trough levels: Collect a minimum of 6 hours after last dose; recommend collection immediately prior to the next dose. Peak levels: collect 60 minutes after the end of IV infusion; 1-2 hours if decreased renal function. |
| Causes for Rejection: | Processed >2 hours after collection and patient is receiving beta-lactam antibiotics structurally similar to gentamicin (e.g. netilmicin, sagamicin and sisomicin) or cephalosporin; collection in a gel tube |
Processing and Shipping
| Specimen Processing: | Centrifuge and assay immediately. If testing is delayed more than 2 hours, then aliquot and freeze the sample, 1.25 mL, 0.2 mL minimum (adult) 0.1 mL minimum (peds),
If specimen is received more than 2 hours after collection, check with the PCU/Clinic to see whether the patient is receiving beta-lactam antibiotics or cephalosporins; if so, cancel the test. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | 7 days refrigerated; 4 weeks frozen. |
| Test Performed at or Referral Lab | Chemistry (Roche-Grand Itasca, Roche-Lakes, Roche-Range, Roche-Ridges, Roche-Southdale, Roche-St. John's, Roche-UMMC East, Roche-UMMC West) |
Interpretive
| Critical Range: | Peak: >16 ug/mL
mg/L = ug/mL |
| Therapeutic Range: | Trough: 1-2 ug/mL
Peak: 5-8 ug/mL mg/L = ug/mL |
| Use: | Monitor therapeutic dosing and evaluate toxicity. Half-life is 1.5-3 h (adult less than 30 y); 3-6 h (adult 30 y or greater); 4-8 h (neonate). |
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