NAIT Serial Monitoring, Maternal Only


Abbrev Code:XMISC   
Order Code:LAB4909Order Name:Laboratory Miscellaneous Order
Synonyms:Neonatal Alloimmune Thrombocytopenia
Methodology:Platelet Antibody Bead Array (PABA) and Flow Cytometry
CPT Codes: 86022 x1
Test Includes:Testing for antibodies against HPA-1a/b, HPA-2a/b, HPA-3a/b, HPA-4a, HPA-5a/b, GPIIb/IIIa, GPIa/IIa, GPIb/IX. GPIV and Class I HLA.
Turnaround Time:Specimens are sent to the reference laboratory Monday-Friday; results are reported within 8 days.
Associated Links:

Platelet Neutrophil Immunology Requisition



Collection Instructions

Specimen:Blood
Optimal Volume:10 mL
Minimum\Peds Volume:6.2 mL
Container:Red (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Room temperature samples are not acceptable.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 5 mL, 3 mL minimum. Store at refrigerated temperature.
Shipping Instructions:Ship refrigerated.
Stability:7 days at refrigerated temperature
Test Performed at or Referral Lab Lab Sendouts  (Versiti)
Referral Lab number:5630


Interpretive

Use:Neonatal alloimmune thrombocytopenia (NAIT) is a rare syndrome caused by maternal IgG antibody directed against a fetal platelet antigen inherited from the father. Approximately 1 in 1000 pregnancies is affected, with about half of the cases occurring in first pregnancies. Although HPA-1A (P1A1) is the dominant human platelet alloantigen (HPA) incompatibility causing NAIT, a significant number of cases are caused by other HPA incompatibilities. 


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