NAIT Serial Monitoring, Maternal Only
| Abbrev Code: | XMISC | ||
| Order Code: | LAB4909 | Order Name: | Laboratory Miscellaneous Order |
| Synonyms: | Neonatal Alloimmune Thrombocytopenia | ||
| Methodology: | Platelet Antibody Bead Array (PABA) and Flow Cytometry | ||
| CPT Codes: | 86022 x1 | ||
| Test Includes: | Testing for antibodies against HPA-1a/b, HPA-2a/b, HPA-3a/b, HPA-4a, HPA-5a/b, GPIIb/IIIa, GPIa/IIa, GPIb/IX. GPIV and Class I HLA. | ||
| Turnaround Time: | Specimens are sent to the reference laboratory Monday-Friday; results are reported within 8 days. | ||
| Associated Links: | |||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 10 mL |
| Minimum\Peds Volume: | 6.2 mL |
| Container: | Red (gel) Alternate Containers: Red (no gel) |
| Causes for Rejection: | Room temperature samples are not acceptable. |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 5 mL, 3 mL minimum. Store at refrigerated temperature. |
| Shipping Instructions: | Ship refrigerated. |
| Stability: | 7 days at refrigerated temperature |
| Test Performed at or Referral Lab | Lab Sendouts (Versiti) |
| Referral Lab number: | 5630 |
Interpretive
| Use: | Neonatal alloimmune thrombocytopenia (NAIT) is a rare syndrome caused by maternal IgG antibody directed against a fetal platelet antigen inherited from the father. Approximately 1 in 1000 pregnancies is affected, with about half of the cases occurring in first pregnancies. Although HPA-1A (P1A1) is the dominant human platelet alloantigen (HPA) incompatibility causing NAIT, a significant number of cases are caused by other HPA incompatibilities. |
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