Phospholipase A2 Receptor, Immunofluorescence
| Abbrev Code: | MMMISC | ||
| Order Code: | LAB4909 | Order Name: | Laboratory Miscellaneous Order |
| Order Instructions: | Can be used in conjunction with a quantitative ELISA (LAB8270) to confirm a positive result, especially for a low-level titer. Since the IFA is more sensitive, it can also be used to detect/follow patients with low level antibodies not detected by ELISA. | ||
| Synonyms: | PLA2R; Anti-PLA2R | ||
| Methodology: | Indirect Immunofluorescence Assay (IFA) | ||
| CPT Codes: | 86255 x1 | ||
| Turnaround Time: | Specimens sent to reference laboratory Monday-Friday; results are reported within 8 days. | ||
| Compliance: | This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared by the U.S. Food and Drug Administration. |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 3 mL |
| Minimum\Peds Volume: | 1.2 mL |
| Container: | Red (gel) Alternate Containers: Red (no gel) |
| Collection Instructions: | Deliver to lab as soon as possible to allow for required processing within 2 hours of collection. |
| Causes for Rejection: | Gross hemolysis |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot a minimum of 0.5 mL serum within 2 hours of collection. Store at refrigerated temperature. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | 8 hours at room temperature; 14 days at refrigerated or frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (Mayo) |
| Referral Lab number: | PLA2I |
Interpretive
| Reference Range: | Negative |
| Limitations: | Absence of circulating anti-phospholipase A2 receptor autoantibodies does not rule out a diagnosis of primary MN. |
| Use: | Distinguishing primary from secondary membranous nephropathy in patients with low levels of anti-phospholipase A2 receptor (PLA2R) antibodies.
Screening for anti-PLA2R antibodies. Monitoring patients with membranous nephropathy at very low antibody titers. |
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