ADAMTS13 Activity and Inhibitor Profile

Abbrev Code:ADM13   
Order Code:LAB8297Order Name:ADAMTS13 Activity and Inhibitor Profile
Methodology:Fluorescence Resonance Energy Transfer (FRET)
CPT Codes: 85397 x1, 85335 x1, 85335 x1
Test Includes:Testing begins with the ADAMTS-13 activity assay to evaluate the percent activity. If the ADAMTS-13 activity is less than 30%, an inhibitor screen will be performed to look for specific ADAMTS-13 inhibition.
Turnaround Time:Specimens sent to reference laboratory Monday-Friday; reported within 2-4 days.
Associated Links:

Mayo Coagulation Guidelines for Specimen Handling and Processing

Collection Instructions

Optimal Volume:2.7 mL (in 2 mL tube) - filled to fill line on the tube
Minimum\Peds Volume:1.8 mL (in 2 mL tube) - filled to fill line on the tube
Container:Blue Na Citrate, 3.2% - fill to fill line on tube
Patient Preparation:Specimen must be collected prior to replacement therapy. Fasting is preferred, but not required.

Processing and Shipping

Specimen Processing:Obtain platelet poor plasma. See Associated Link for guidelines on processing. Centrifuge and aliquot 2 mL in 2 plastic vials each containing 1 mL. Store frozen. Must be frozen within 4 hours of collection.
Shipping Instructions:Ship frozen.
Stability:14 days frozen
Test Performed at or Referral Lab Lab Sendouts  (Mayo)
Referral Lab number:ADM13


Reference Range:ADAMTS13 ACTIVITY ASSAY: > or =70%
ADAMTS13 INHIBITOR SCREEN (if reflexed): Negative
ADAMTS13 BETHESDA TITER (if reflexed): <0.4 BU
Use:Assisting with the diagnosis of congenital or acquired thrombotic thrombocytopenic purpura.

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