ADAMTS13 Activity and Inhibitor Profile
| Abbrev Code: | ADM13 | ||
| Order Code: | LAB8297 | Order Name: | ADAMTS13 Activity and Inhibitor Profile |
| Methodology: | Fluorescence Resonance Energy Transfer (FRET) | ||
| CPT Codes: | 85397 x1, 85335 x1, 85335 x1 | ||
| Test Includes: | Testing begins with the ADAMTS-13 activity assay to evaluate the percent activity. If the ADAMTS-13 activity is less than 30%, an inhibitor screen will be performed to look for specific ADAMTS-13 inhibition. | ||
| Turnaround Time: | Specimens sent to reference laboratory Monday-Friday; reported within 2-4 days. | ||
| Associated Links: | Mayo Coagulation Guidelines for Specimen Handling and Processing |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.7 mL (in 2 mL tube) - filled to fill line on the tube |
| Minimum\Peds Volume: | 1.8 mL (in 2 mL tube) - filled to fill line on the tube |
| Container: | Blue Na Citrate, 3.2% - fill to fill line on tube |
| Patient Preparation: | Specimen must be collected prior to replacement therapy. Fasting is preferred, but not required. |
Processing and Shipping
| Specimen Processing: | Obtain platelet poor plasma. See Associated Link for guidelines on processing. Centrifuge and aliquot 2 mL in 2 plastic vials each containing 1 mL. Store frozen. Must be frozen within 4 hours of collection. |
| Shipping Instructions: | Ship frozen. |
| Stability: | 14 days frozen |
| Test Performed at or Referral Lab | Lab Sendouts (Mayo) |
| Referral Lab number: | ADM13 |
Interpretive
| Reference Range: | ADAMTS13 ACTIVITY ASSAY: > or =70%
ADAMTS13 INHIBITOR SCREEN (if reflexed): Negative ADAMTS13 BETHESDA TITER (if reflexed): <0.4 BU |
| Use: | Assisting with the diagnosis of congenital or acquired thrombotic thrombocytopenic purpura. |
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