BRCA HRR Deficiency NGS Panel with Fusion

Abbrev Code:BRCA NGSO   
Order Code:LAB8273Order Name:BRCA HRR Deficiency NGS Panel with Fusion
Synonyms:BRCA1; BRCA2; homologous recombination deficiency; HRD; PARP; PARPi; PALB2
Methodology:Next Generation Sequencing
CPT Codes: 81455 x1, G0452 x1
Test Includes:See Beaker NGS Oncology Panel Gene List for a comprehensive list of genes contained within each available panel.
Turnaround Time:Performed Mon-Fri; results are reported within 10 days.

Collection Instructions

Specimen:Fixed tissue slides; paraffin block
Optimal Volume:9 unstained slides (10 microns thick) and 1 H&E slide (10 microns thick) fixed tissue
Minimum\Peds Volume:5 unstained slides (10 microns thick) and 1 H&E slide (10 microns thick) fixed tissue
Causes for Rejection:Fixative other than formalin, decalcified tissue

Processing and Shipping

Specimen Processing:Do not process. Store at room temperature.
Shipping Instructions:Ship at room temperature. Do not refrigerate or freeze.
Test Performed at or Referral Lab UM Molecular Diagnostics (M)  (UMMC East Bank)


Use:Next Generation Sequencing of DNA to assess for somatic mutations in the indicated gene panel. NGS Fusion panel is included for detection of translocations (including NTRK).

This panel is intended for the assessment of somatic mutations in BRCA1, BRCA2, PALB2 and other genes associated with homologous recombination DNA repair. Results from this test are indicated in the assessment of tumors for homologous recombination deficiency (HRD) to inform selection of appropriate therapy (including PARP inhibitors) and provide additional clinical information regarding response to other chemotherapeutic agents. Please contact the Molecular Diagnostic Laboratory at 612-273-8445 for more information.

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