Endometrial Adenocarcinoma NGS Panel
| Abbrev Code: | ENDOMET | ||
| Order Code: | LAB8290 | Order Name: | Endometrial Adenocarcinoma NGS Panel |
| Synonyms: | POLE; TP53 | ||
| Methodology: | Next Generation Sequencing | ||
| CPT Codes: | 81445 x1 | ||
| Test Includes: | See Beaker NGS Oncology Panel Gene List for a comprehensive list of genes contained within each available panel. | ||
| Turnaround Time: | Performed Mon-Fri; results are reported within 10 days. | ||
Collection Instructions
| Specimen: | Fixed tissue slides; paraffin block |
| Optimal Volume: | 9 unstained slides (10 microns thick) and 1 H&E slide (10 microns thick) fixed tissue |
| Minimum\Peds Volume: | 5 unstained slides (10 microns thick) and 1 H&E slide (10 microns thick) fixed tissue |
| Container: | Plastic leakproof container, sterile |
| Causes for Rejection: | Fixative other than formalin, decalcified tissue |
Processing and Shipping
| Specimen Processing: | Do not process. Store at room temperature. |
| Shipping Instructions: | Ship at room temperature. Do not refrigerate or freeze |
| Test Performed at or Referral Lab | UM Molecular Diagnostics (M) (UMMC East Bank) |
Interpretive
| Use: | Next Generation Sequencing of DNA to assess for somatic mutations in the indicated gene panel. NGS Fusion panel is included for detection of translocations (including NTRK).
Endometrial cancers are most common types of uterine cancer. The Cancer Genome Atlas (TCGA) has identified several genes often mutated in this type of cancer which include CTNNB1, POLE, TP53. Genetic analysis not only helps in understanding of the molecular mechanism but also offer insight into available targeted therapies. |
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