Endometrial Adenocarcinoma NGS Panel

Abbrev Code:ENDOMET   
Order Code:LAB8290Order Name:Endometrial Adenocarcinoma NGS Panel
Synonyms:POLE; TP53
Methodology:Next Generation Sequencing
CPT Codes: 81445 x1
Test Includes:See Beaker NGS Oncology Panel Gene List for a comprehensive list of genes contained within each available panel.
Turnaround Time:Performed Mon-Fri; results are reported within 10 days.

Collection Instructions

Specimen:Fixed tissue slides; paraffin block
Optimal Volume:9 unstained slides (10 microns thick) and 1 H&E slide (10 microns thick) fixed tissue
Minimum\Peds Volume:5 unstained slides (10 microns thick) and 1 H&E slide (10 microns thick) fixed tissue
Container:Plastic leakproof container, sterile
Causes for Rejection:Fixative other than formalin, decalcified tissue

Processing and Shipping

Specimen Processing:Do not process. Store at room temperature.
Shipping Instructions:Ship at room temperature. Do not refrigerate or freeze
Test Performed at or Referral Lab UM Molecular Diagnostics (M)  (UMMC East Bank)


Use:Next Generation Sequencing of DNA to assess for somatic mutations in the indicated gene panel. NGS Fusion panel is included for detection of translocations (including NTRK).

Endometrial cancers are most common types of uterine cancer.  The Cancer Genome Atlas (TCGA) has identified several genes often mutated in this type of cancer which include CTNNB1, POLE, TP53. Genetic analysis not only helps in understanding of the molecular mechanism but also offer insight into available targeted therapies.

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