Platelet Antigen Genotyping Panel
| Abbrev Code: | PAGENO | ||
| Order Code: | LAB4308 | Order Name: | Platelet Antigen Typing I |
| Synonyms: | Platelet Antigen Genotyping, Level 1 | ||
| Methodology: | PCR and fluorescent hydrolysis probes | ||
| CPT Codes: | 81105 x1, 81106 x1, 81107 x1, 81108 x1, 81109 x1, 81110 x1, 81111 x1, 81112 x1 | ||
| Test Includes: | HPA-1, 2, 3, 4, 5,6, 9 and 15 | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Fri; results are reported within 7 days. | ||
| Special Instructions: | A signed informed consent in the patient's medical record is required; the consent should not be sent to the laboratory. The link to the Genetic Testing Consent Form is provided as a convenience for the providers and genetic counselors. | ||
| Associated Links: | |||
Collection Instructions
| Specimen: | Blood, amniotic fluid, cord blood or cultured amniocytes |
| Optimal Volume: | 5 mL blood; 1 mL cord blood; 15 mL amniotic fluid, or 5 x 10 mg cultured amniocytes |
| Minimum\Peds Volume: | 3 mL blood (adult); 2 mL blood (pediatric); 7 mL amniotic fluid. Call laboratory for minimum of other specimens types (1-800-245-3117 ext. 6250) |
| Container: | Purple (EDTA) Alternate Containers: Plastic leakproof container, sterile |
| Collection Instructions: | Use purple (EDTA) for blood or cord blood; plastic leakproof container for other specimens. |
Processing and Shipping
| Specimen Processing: | All specimens: do not process. Store at room temperature. |
| Shipping Instructions: | Ship at room temperature or refrigerated. |
| Test Performed at or Referral Lab | Lab Sendouts (Versiti) |
| Referral Lab number: | 5600 |
Interpretive
| Reference Range: | Interpretive report. |
| Limitations: | New variant alleles that posses polymorphisms within the region targeted by the oligonucleotide primers may not be identified with these assays. |
| Use: | Confirmation of Platelet Antibody Specificity: Genotyping can be used in PTP and MPR cases to confirm the specificity of platelet-specific antibodies present in the patient's serum. Genotyping is particularly helpful in confirming antibody specificity in cases involving low frequency or "new" platelet alloantigens. Samples with Low Platelet Counts: In contrast to standard serologic platelet typing tests, genotyping does not require that blood samples contain adequate numbers of platelets since it utilizes DNA isolated from leukocytes or other cells. |
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